PROPOLEO Y DIABETES
Items 1 - 6 of 6
1: Clin Biochem. 2005 Feb;38(2):191-6.
Effects of caffeic acid phenethyl ester on lipid peroxidation and antioxidant enzymes in diabetic rat heart.
Okutan H, Ozcelik N, Yilmaz HR, Uz E.
Department of Cardiovascular Surgery,
OBJECTIVES: The risk for cardiovascular disease is significantly high in diabetes mellitus. Experimental evidence suggests that oxidative stress plays a dominant role in the pathogenesis of diabetes mellitus. Caffeic acid phenethyl ester (
2: Pharmacol Res. 2005 Feb;51(2):147-52.
Effects of propolis on blood glucose, blood lipid and free radicals in rats with diabetes mellitus.
Fuliang HU, Hepburn HR, Xuan H, Chen M, Daya S, Radloff SE.
College of Animal Science,
The effects of ethanol (EEP) and water (WSD) extracts of propolis collected from north
PMID: 15629260 [PubMed - indexed for MEDLINE]
3: Asia Pac J Clin Nutr. 2004;13(Suppl):S66.
Effect of combined propolis-ethanol-extract and Shaoyao-Gancao-tang on blood sugar levels in rabbits with alloxan induced experimental diabetes.
Wang NZ, Li D.
Dept of Food Science,
Background - Propolis, a bee-hive product, has been used as a Chinese folk medicine for thousand years, with reported beneficial effects on various clinical conditions. Shaoyao-Gancao-tang, a prescription Chinese Medicine, is a mixture of the water extract of liquorice (Radix Glycyrrhizac) and peony (Paeonialaciflora) roots. Objective - To investigate the effect of combined propolis-ethanol-extract and Shaoyao-Gancao-tang (PSG) on blood sugar levels of rabbits following alloxan induced experimental diabetes. Design - PSG was prepared as a 1:1 mixture of propolis-ethanol-extract and water extract of liquorice and peony roots. Fasting (8 h) blood sugar > 180mg/mL was considered as experimental diabetes after rabbits were treated with 100mg/kg of 5% alloxan for 72 h. Blood sugar levels of the diabetic rabbits were measured after they were given a 0.3g/kg oral dose of PSG (n=8) or propolis (n=8) at 6 and 24 h, respectively. A control group of diabetic rabbits (n=8) had no PSG or propolis administered and were tested at the same time points. Outcomes - Compared with control group, diabetic rabbits treated with PSG or propolis showed a significant reduction in blood sugar levels at 24 h (P<0.05), and PSG was more potent than propolis alone. Conclusions - The results indicated that propolis-ethanol-extract has a beneficial effect on reduction of blood sugar levels in alloxan induced diabetic rabbits, and may have a synergistic effect with Shaoyao-Gancao-tang.
PMID: 15294555 [PubMed - in process]
4: Altern Ther Health Med. 2004 May-Jun;10(3):78-9.
PMID: 15154157 [PubMed - indexed for MEDLINE]
5: J Agric Food Chem. 2004 May 19;52(10):3083-8.
Identification of metabolites in plasma and urine of Uruguayan propolis-treated rats.
Kumazawa S, Shimoi K, Hayashi K, Ishii T, Hamasaka T, Nakayama T.
Laboratory of Functional Food Science and COE Program in the 21st Century,
Propolis is a resinous substance collected by honeybees from various plant sources. It is extensively used in food and beverages to improve health and prevent diseases such as heart disease, diabetes, and cancer. To investigate the absorption and metabolism of the components in propolis, in the present study, we administered ethanol extracts of Uruguayan propolis (poplar type propolis) orally to rats and analyzed their plasma and urine by high-performance liquid chromatography with photodiode array and mass spectrometric detection. After deconjugation of the components by beta-glucuronidase/sulfatase treatment of the specimen, pinobanksin 5-methyl ether, pinobanksin, kaempferol, chrysin, pinocembrin, and galangin were detected in plasma of rats orally administered propolis. These compounds were detected also in urine after beta-glucuronidase/sulfatase treatment. Furthermore, pinobanksin 5-methyl ether, pinobanksin, chrysin, pinocembrin, and galangin were present in the urine also in free form. These results suggest that flavonoids in propolis are metabolized and circulate in the body after oral administration of propolis.
PMID: 15137857 [PubMed - indexed for MEDLINE]
6: Biochem Pharmacol. 1983 Apr 1;32(7):1141-8.
Flavonoids, a class of natural products of high pharmacological potency.
A review has been presented of the biochemistry and pharmacology of a class of natural products, the flavonoids. These substances which are widely distributed in the plant kingdom and present in considerable quantities in common food products, spices and beverages have in a concentrated form (Propolis) been used since ancient times by physicians and laymen to treat a great variety of human diseases but they have yet to pass the tests of modern, controlled, clinical experimentation. An attempt has been made to present the fundamental evidence from the basic biological sciences which is required to stimulate the interest of the clinicians in this new field. The few existing reports on the careful pharmacodynamic, pharmacokinetic and clinical studies which have been made have been summarized to provide a basis for a full-scale investigation of the therapeutic potential of flavonoids.
PMID: 6342623 [PubMed - indexed for MEDLINE]