BIBLIOGRAFIA PROPOLEOS
ANTIBIOTICO
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Items 1 - 84 of 84 |
One page. |
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1:
Rev
Bras Enferm. 2005 Mar-Apr;58(2):208-13. |
[Wound treatment: scientific production analysis published in the
Revista Brasileira de Enfermagem from 1970-2003]
[Article in Portuguese]
Pereira AL, Bachion MM.
Aluna do Programa de Pos-Graduacao Mestrado em Enfermagem, da Faculdade de
Enfermagem da Universidade Federal de Goias. ginha.ange@bol.com.br
This systematic review aimed to analyze the scientific production concerning the
use of products in the treatment of wounds, published by REBEn from 1970 to
2003. We consulted all numbers of the journal published in the period,
identifying 41 articles of interest. After an appraisal reading we included 11
papers in the sample. We identified a larger publication in the decade of 1990,
prevailing authors of the attendance area, almost-experimental plan and
experience repor. The studied products were papain, propolis, sugar,
PMID: 16334190 [PubMed - in process]
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2: Int J Antimicrob Agents. 2005
Nov;26(5):343-56. |
Antimicrobial activity of flavonoids.
Cushnie TP, Lamb AJ.
Flavonoids are ubiquitous in photosynthesising cells and are commonly found in
fruit, vegetables, nuts, seeds, stems, flowers, tea, wine, propolis and honey.
For centuries, preparations containing these compounds as the principal
physiologically active constituents have been used to treat human diseases.
Increasingly, this class of natural products is becoming the subject of
anti-infective research, and many groups have isolated and identified the
structures of flavonoids possessing antifungal, antiviral and antibacterial
activity. Moreover, several groups have demonstrated synergy between active
flavonoids as well as between flavonoids and existing chemotherapeutics.
Reports of activity in the field of antibacterial flavonoid research are widely
conflicting, probably owing to inter- and intra-assay variation in
susceptibility testing. However, several high-quality investigations have
examined the relationship between flavonoid structure and antibacterial
activity and these are in close agreement. In addition, numerous research
groups have sought to elucidate the antibacterial mechanisms of action of
selected flavonoids. The activity of quercetin, for example, has been at least
partially attributed to inhibition of DNA gyrase. It has also been proposed
that sophoraflavone G and (-)-epigallocatechin gallate inhibit cytoplasmic
membrane function, and that licochalcones A and C inhibit energy metabolism.
Other flavonoids whose mechanisms of action have been investigated include
robinetin, myricetin, apigenin, rutin, galangin,
2,4,2'-trihydroxy-5'-methylchalcone and lonchocarpol A. These compounds
represent novel leads, and future studies may allow the development of a
pharmacologically acceptable antimicrobial agent or class of agents.
Publication Types:
·
Review
PMID: 16323269 [PubMed - indexed for MEDLINE]
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3: Am J Kidney Dis. 2005
Dec;46(6):e125-9. |
Acute renal failure induced by a Brazilian variety of propolis.
Li YJ, Lin JL, Yang CW, Yu CC.
Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Propolis is a resinous substance collected by honeybees and used in hive
construction and maintenance. Cumulative evidence suggests that propolis may
have anti-inflammatory, antibiotic, antioxidant, antihepatotoxic, and antitumor
properties. In addition to topical applications, products containing propolis
have been used increasingly as dietary supplements. Although reports of
allergic reactions are not uncommon, propolis is reputed to be relatively
nontoxic. Its systemic toxicity is rarely reported and hence may be
underestimated. This is the first report of propolis-induced acute renal
failure. A 59-year-old man required hemodialysis for acute renal failure. The
patient had cholangiocarcinoma and had ingested propolis for 2 weeks before
presentation. Renal function improved after propolis withdrawal, deteriorated
again after reexposure, and then returned to a normal level after the second
propolis withdrawal. This case indicates that propolis can induce acute renal
failure and emphasizes the need for vigilance and care when propolis is used as
a medicine or dietary supplement.
Publication Types:
PMID: 16310564 [PubMed - indexed for MEDLINE]
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4: J Agric Food Chem. 2005 Nov
16;53(23):8957-62. |
Evaluation of the cytotoxicity, genotoxicity, mutagenicity, and
antimutagenicity of propolis from Tucuman, Argentina.
Nieva Moreno MI,
Zampini IC, Ordonez RM, Jaime GS, Vattuone MA, Isla MI.
Instituto de Estudios Vegetales Dr Antonio Rodolfo Sampietro, Facultad de
Bioquimica, Quimica y Farmacia, Universidad Nacional de Tucuman, Ayacucho 461,
4000 San Miguel de Tucuman, Argentina.
This study
evaluates the toxic, genotoxic/mutagenic, and antimutagenic effects of propolis
extract from Amaicha del Valle,
PMID: 16277388 [PubMed - indexed for MEDLINE]
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5: Mem Inst Oswaldo Cruz. 2005 Aug;100(5):563-6.
Epub 2005 Sep 15. |
Propolis: anti-Staphylococcus aureus activity and synergism with
antimicrobial drugs.
Fernandes Junior A,
Balestrin EC, Betoni JE, Orsi Rde O, da Cunha Mde L,
Montelli AC.
Departamento de Microbiologia e Imunologia, Instituto de Biociencias,
Universidade Estadual Paulista Julio de Mesquita Filho, Unesp, Botucatu, SP,
Brazil. ary@ibb.unesp.br
Propolis is a natural resinous substance collected by bees from tree exudates
and secretions. Its antimicrobial activity has been investigated and inhibitory action
on Staphylococcus aureus growth was evaluated. The in vitro synergism between
ethanolic extract of propolis (EEP) and antimicrobial drugs by two
susceptibility tests (Kirby and Bauer and E-Test) on 25 S. aureus strains was
evaluated. Petri dishes with sub-inhibitory concentrations of EEP were
incubated with 13 drugs using Kirby and Bauer method and synergism between EEP
and five drugs [choramphenicol (CLO), gentamicin (GEN), netilmicin (NET),
tetracycline (TET), and vancomycin (VAN)] was observed. Nine drugs were assayed
by the E-test method and five of them exhibited a synergism [CLO, GEN, NET,
TET, and clindamycin (CLI)]. The results demonstrated the synergism between EEP
and antimicrobial drugs, especially those agents that interfere on bacterial
protein synthesis.
PMID: 16184236 [PubMed - indexed for MEDLINE]
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6:
J
Ethnopharmacol. 2005 Oct 3;101(1-3):243-8. |
Detection of galangin-induced cytoplasmic membrane damage in
Staphylococcus aureus by measuring potassium loss.
Cushnie TP, Lamb AJ.
Galangin is one of the active antimicrobial principles of propolis or 'bee
glue' and Helichrysum aureonitens, a perennial herb used by South African
indigenes to treat infection. The effect of this compound and antibacterial
agents with known mechanisms of action upon the cytoplasmic membrane integrity
of Staphylococcus aureus was investigated by comparing potassium loss profiles
from bacterial cell suspensions. Using an agar dilution assay, the minimum
inhibitory concentrations (MICs) of the flavonol galangin, the bacteriostatic
antibiotic novobiocin and the bactericidal antibiotic penicillin G against
Staphylococcus aureus NCTC 6571 were determined as being 50 microg/mL, 62.5
ng/mL and 31.3 ng/mL, respectively. When 5x10(7)cfu/mL Staphylococcus aureus
were suspended in 'potassium-free' media containing 50 microg/mL galangin, a
60-fold decrease in viability was observed after 12 h. Populations of 1x10(9)
cfu/mL Staphylococcus aureus incubated for 12 h in 50 microg/mL galangin lost
21% more potassium than untreated control populations. Novobiocin had no effect
on potassium loss, but populations incubated in 31.3 ng/mL penicillin G
exhibited a 6% increase in potassium loss. This data clearly demonstrates that
galangin causes a significant increase in potassium loss from Staphylococcus
aureus cells, which may be attributed to either direct damage to the
cytoplasmic membrane or indirect damage effected through autolysis/weakening of
the cell wall and consequent osmotic lysis.
PMID: 15985350 [PubMed - indexed for MEDLINE]
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7:
Phytother
Res. 2005 Mar;19(3):198-202. |
Antibacterial effect of plant extracts against Helicobacter pylori.
Nostro A, Cellini L, Di Bartolomeo S,
Di Campli E, Grande R, Cannatelli MA,
Marzio L, Alonzo V.
Pharmaco-Biological
Department, University of Messina, Messina, Italy.
The aim of this work was to evaluate the antibacterial effect of plant extracts
as alternative and[sol ]or as active agents supporting antibiotics for treating
Helicobacter pylori infection. The effect of either, ethanolic or aqueous
extracts from 17 plant materials were studied against one H. pylori standard
strain and 11 clinical isolates using a disc diffusion test and by evaluating
the minimum inhibitory concentration (MIC) on solid media. An inhibitory
activity against H. pylori strains was recorded in a large percentage of tested
plants. MIC values of ethanolic extracts were from two to four concentration
steps lower than the aqueous ones. In particular, ethanolic extracts of Cuminum
cyminum L. and Propolis expressed MIC90 values of 0.075 mg/mL. The results show
a significant in vitro effect of plant extracts against H. pylori that could be
considered a valuable support in the treatment of the infection and may
contribute to the development of new and safe agents for inclusion in anti-H.
pylori regimens. Copyright 2005 John Wiley & Sons, Ltd.
PMID: 15934015 [PubMed - indexed for MEDLINE]
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8: Int J Gynaecol Obstet. 2005
May;89(2):127-32. |
Propolis solution for the treatment of chronic vaginitis.
Imhof M, Lipovac M, Kurz Ch, Barta J, Verhoeven HC, Huber JC.
Department
of Obstetrics and Gynecology, AKH Vienna, University of Vienna, Vienna,
Austria. martin.imhof@akh.ac.at
OBJECTIVE: To evaluate the efficacy of 5% propolis solution in recurrent
vaginitis. METHOD: Fifty-four patients with recurrent vaginal infections having
undergone at least one cycle of antibiotic treatment were instructed to apply a
5% aqueous propolis solution as a vaginal douche for seven days. Vaginal smears
and specific symptoms were evaluated at baseline and 14 days after treatment.
Long-term well-being was assessed by telephone interview six months after
follow-up. RESULT: At the follow-up, the vaginal smears of 41 patients (75.9%)
had improved. Forty-seven patients (87%) reported reliefs concerning at least
one complaint. Associated improvement of smear and well-being was observed in
36 women (66.7%). After 6 months, 33 patients (61.1%) were satisfied with their
condition without having undergone further treatment. CONCLUSION: Propolis may
have a role as an alternative treatment for chronic vaginal infection.
Publication Types:
PMID: 15847875 [PubMed - indexed for MEDLINE]
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9:
Phytomedicine.
2005 Mar;12(3):221-8. |
Antibacterial activity of Turkish propolis and its qualitative and
quantitative chemical composition.
Popova M, Silici S, Kaftanoglu O, Bankova V.
The antibacterial activity of propolis from different regions of
PMID: 15830845 [PubMed - indexed for MEDLINE]
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10:
Contact
Dermatitis. 2005 Feb;52(2):96-101. |
Rosacea and contact allergy to cosmetics and topical
medicaments--retrospective analysis of multicentre surveillance data 1995-2002.
Jappe U, Schnuch A, Uter W.
Department of Dermatology, University of Heidelberg, Heidelberg, Germany.
uta_jappe@med.uni-heidelberg.de
The role of contact allergy in rosacea has rarely been investigated. In this
retrospective study, 361 out of 76,697 patients tested and documented by the
Information Network of Departments of Dermatology between 1995 and 2002 had
rosacea. Patch tests included standard series and constituents of cosmetics and
topical medicaments. 118/361 had additionally been patch tested with their own
cosmetics/medicaments. Positive reactions occurred to nickel (II) sulfate in
9.3%, fragrance mix in 8.8%, thimerosal in 6.9%, Myroxylon pereirae resin in
5.9%, potassium dichromate in 4.6% and propolis in 2.8%. Whereas rosacea
patients had a significantly higher risk of contact allergy to propolis
compared to the remaining patients, in an age- and sex-adjusted analysis,
contact allergy to nickel was significantly less frequent in this group. For
Lyral, the risk was elevated, albeit not significantly. Only 2/329 patients
were positive to neomycin sulfate and 1/100 to gentamicin sulfate, among the
panel of (topical) antibiotics tested. Among 118 patients tested with their own
products, 3 were tested to metronidazole, 1 reacting positively. Irritant or
doubtful patch test reactions were provoked by various substances (vehicles,
oxidants and preservatives of various creams), which might also be clinically
important, considering the heightened sensitivity of rosaceous skin.
Publication Types:
PMID: 15725288 [PubMed - indexed for MEDLINE]
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11: J Agric Food Chem. 2005 Feb
23;53(4):1166-72. |
Some chemical composition and biological activity of northern Argentine
propolis.
Isla MI, Paredes-Guzman JF,
Nieva-Moreno MI,
Koo H, Park YK.
Department
of Food Science, College of Food Engineering, State University of Campinas,
P.O. Box 6177, 13083-970, Campinas, Sao Paulo, Brazil.
Twenty-five samples of propolis were collected from seven different regions in
northern
PMID: 15713035 [PubMed - indexed for MEDLINE]
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12:
Fitoterapia.
2004 Dec;75(7-8):683-9. |
New polyisoprenylated benzophenones from Venezuelan propolis.
Trusheva B, Popova M, Naydenski H, Tsvetkova I, Gregorio Rodriguez J,
Bankova V.
Two new polyisoprenylated benzophenones, 18-ethyloxy-17-hydroxy-17,18-dihydroscrobiculatone
A and 18-ethyloxy-17-hydroxy-17,18-dihydroscrobiculatone B, together with the
known scrobiculatones A and B, were isolated from Venezuelan propolis. The
scrobiculatones A and B showed significant antibacterial activity and moderate
toxicity to Artemia salina nauplii.
PMID: 15567244 [PubMed - indexed for MEDLINE]
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13:
FEMS
Microbiol Lett. 2004 Nov 1;240(1):111-6. |
Galangin expresses bactericidal activity against multiple-resistant
bacteria: MRSA, Enterococcus spp. and Pseudomonas aeruginosa.
Pepeljnjak S, Kosalec I.
The antimicrobial activity of three propolis ethanol extracts (EEP) was
examined for various Gram-negative and Gram-positive bacterial species,
including multiple-resistant Staphylococcus aureus, Enterococcus spp. and
Pseudomonas aeruginosa strains. EEP had a good bactericidal activity against
Gram-positive species, and all multiple-resistant bacterial strains tested were
sensitive to EEP. Minimal inhibitory concentrations (MICs) were lower in
samples of higher flavonoid content (from 0.65 to 7.81 mg mL(-1)), indicating
the influence of the concentration of some potent bactericidal compound(s) in
propolis or synergism among some bactericidal compounds. Antimicrobial-guided
separation of flavonoid aglycones (bioassay in situ on thin-layer chromatogram)
showed that galangin (3,5,7-trihydroxyflavone) is one compound in EEP with
bactericidal activity. Galangin was isolated by preparative chromatography.
After determining the quantity present, the MIC against multiple-resistant
bacteria was determined. The MIC of galangin against multiple-resistant
bacterial strains was significantly lower (from 0.16 to 0.44 mg mL(-1), p <
0.05) than that of EEP. The bactericidal activity of galangin against P.
aeruginosa strains was present at 0.17+/-0.05 mg mL(-1).
PMID: 15500987 [PubMed - indexed for MEDLINE]
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14:
Pesqui
Odontol Bras. 2004 Apr-Jun;18(2):174-9. Epub 2004 Aug 5. |
Natural medicaments in endodontics -- a comparative study of the
anti-inflammatory action.
Silva FB, Almeida JM, Sousa SM.
Center of Biological Sciences and Professions of Health, University of Sacred
Heart, Bauru.
The objective of this study was to evaluate the irritant potential of propolis,
Casearia sylvestris, Otosporin and saline solution (control). Twenty-eight male
Wistar rats were selected, anesthetized and four experimental sites were
designed on their backs. Injections of 2% Evans blue were intravenously
administered in the lateral caudal vein and 0.1 ml of the tested solutions was
injected intradermally into the experimental sites. The animals were killed
1/2, 1, 3 and 6 hours after the injection of the solutions. Each piece of skin
containing the lesion was immersed in formamide and incubated at 45 masculine C
for 72 h. After filtration, optical density was measured in a
spectrophotometer. Data were statistically analyzed by a 2-way non-parametric
test. The highest values of extracted dye were observed at 3 hours
characterizing a peak in the inflammatory process. Propolis was the least
irritant solution. The natural medicaments tested in this study may be a
valuable alternative for endodontic treatment.
Publication Types:
PMID: 15311323 [PubMed - indexed for MEDLINE]
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15:
Pharmacol
Res. 2004 Mar;49(3):287-92. |
Effect of water extract of Turkish propolis on tuberculosis infection in
guinea-pigs.
Yildirim Z, Hacievliyagil S,
Kutlu NO, Aydin NE, Kurkcuoglu M, Iraz M, Durmaz R.
Department
of Pulmonary Medicine, University of Inonu School of Medicine, Turgut Ozal
Medical Centre, Kampus, 44069, Malatya, Turkey. zyildirim@inonu.edu.tr
Mycobacterium tuberculosis (H(37)R(v))-infected guinea-pig model was used to
investigate the effect of water extract of propolis (WEP). After subcutaneous
inoculation of tubercle bacilli, each animal received oral WEP (n=9), isoniazid
(n=5) or saline (n=6) as placebo and were sacrificed 30 days later. Formation
of necrosis was less prominent in the group treated with WEP, but was not
statistically significant (P>0.05). The granuloma formation in the same
group was more prominent than the placebo and isoniazid groups; however, this
finding failed to reach statistical significance by the Kruskal-Wallis test
(P>0.05). These findings suggest that Turkish WEP may have a limited effect
on the development of tuberculosis infection in this guinea-pig model.
PMID: 14726226 [PubMed - indexed for MEDLINE]
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16:
Microbiol
Res. 2003;158(4):353-7. |
In vitro antimicrobial activity of propolis and synergism between propolis
and antimicrobial drugs.
Stepanovic S, Antic N, Dakic I, Svabic-Vlahovic M.
Department of Bacteriology, Institute of Microbiology and Immunology, School of
Medicine, University of Belgrade, Dr Subotica 1, 11000 Belgrade, Serbia. stepan@afrodita.rcub.bg.ac.yu
The aim of this study was to investigate antimicrobial properties of ethanolic
extract of 13 propolis (EEP) samples from different regions of Serbia against
39 microorganisms (14 resistant or multiresistant to antibiotics), and to
determine synergistic activity between antimicrobials and propolis.
Antimicrobial activity of propolis samples was evaluated by agar diffusion and
agar dilution method. The synergistic action of propolis with antimicrobial
drugs was assayed by the disc diffusion method on agar containing subinhibitory
concentrations of propolis. Obtained results indicate that EEP, irrespectively
of microbial resistance to antibiotics, showed significant antimicrobial
activities against Gram-positive bacteria (MIC 0.078%-1.25% of EEP) and yeasts
(0.16%-1.25%), while Gram-negative bacteria were less susceptible
(1.25%-->5%). Enterococcus faecalis was the most resistant Gram-positive
bacterium, Salmonella spp. the most resistant Gram-negative bacteria, and
Candida albicans the most resistant yeast. EEP showed synergism with selected
antibiotics, and displayed ability to enhance the activities of antifungals.
The shown antimicrobial potential of propolis alone or in combination with
certain antibiotics and antifungals is of potential medical interest.
PMID: 14717457 [PubMed - indexed for MEDLINE]
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17:
Clin
Chim Acta. 2003 Dec;338(1-2):11-6. |
Protective role of Egyptian propolis against tumor in mice.
El-khawaga OA, Salem TA, Elshal MF.
Chemistry Department, Faculty of Science, Mansoura University, Mansoura City,
Egypt. elkhawaga70s@mans.edu.eg
BACKGROUND: Propolis has numerous biologic activities including antibiotic,
antifungal, antiviral and anti-inflammatory properties. The present work is
aimed to study the effect of crude Egyptian propolis on tumor in mice induced
by Ehrlich ascitis carcinoma (EAC) cell line. RESULTS: The administration of
propolis (160 mg/kg body weight), by gastric intubation 2 h before the
intraperitoneal injection of EAC, effectively inhibited tumor growth and the proliferation
of EAC. The tumor volume was markedly reduced from 7+/-0.9 ml in EAC-infected
mice to 1.6+/-0.95 ml in propolis-treated mice. Also, the lipid peroxide level
which was 13.3+/-1.24 nmol malodialdehyde (MDA)/mg protein in EAC infected mice
was significantly decreased to 3.3+/-2.1 nmol MDA/mg protein. Reduced
glutathione (GSH) and glutathione S-transferase (GST) concentrations were
markedly increased in propolis-treated mice. This effect was associated with
inhibition of cell cycle progression and induction of apoptosis. Administration
of propolis 2 h before injection of EAC arrested cells in G0/G1 phase and
resulted in a decrease in the viability, DNA, total RNA and protein level of
tumor cells. CONCLUSIONS: Crude Egyptian propolis has a strong inhibitory
activity against tumors. The anti-tumor mechanism may be mediated by preventing
oxidative damage and induction of apoptosis.
PMID: 14637260 [PubMed - indexed for MEDLINE]
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18:
J
Ethnopharmacol. 2003 Oct;88(2-3):189-93. |
Flavonoids and trypanocidal activity of Bulgarian propolis.
Prytzyk E, Dantas AP, Salomao K, Pereira AS, Bankova VS, De Castro SL, Neto FR.
Ladetec, Instituto de Quimica, Universidade Federal do Rio de Janeiro, Ilha do
Fundao, Cidade Universitaria, CT Bl. A, 21949-900
Acetone and ethanol extracts of two Bulgarian propolis samples (Bur and Lov)
were investigated by high temperature high resolution gas chromatography
coupled to mass spectrometry (HT-HRGC-MS), and their activity against
Trypanosoma cruzi was evaluated. The ethanol extracts--Et-Bur and
Et-Lov--showed similar composition, with a high content of flavonoids, and
strong inhibitory activity against T. cruzi proliferative epimastigotes, which
were more susceptible than trypomastigotes. In the presence of blood, the
activity of Et-Bur or Et-Lov against trypomastigotes was similar to that of the
standard drug, crystal violet. Both extracts also showed similar and
significant activity against Staphylococcus aureus and Candida albicans, while
being inactive against Escherichia coli. The acetone extract, Ket-Bur, was more
active than Et-Bur against both forms of T. cruzi.
PMID: 12963141 [PubMed - indexed for MEDLINE]
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19: J Med Microbiol. 2003 May;52(Pt
5):417-9. |
Inhibition of Helicobacter pylori growth in vitro by Bulgarian propolis:
preliminary report.
Boyanova L, Derejian S, Koumanova R, Katsarov N, Gergova G, Mitov I, Nikolov R, Krastev Z.
Department
of Microbiology, Medical University of Sofia, Sofia, Bulgaria.
l.boyanova@lycos.com
Bee glue (propolis) possesses antimicrobial, anti-inflammatory, anaesthetic and
immunostimulating activities. The aim of the study was to evaluate the
inhibitory effect of Bulgarian propolis on Helicobacter pylori growth in vitro.
Activity of 30% ethanolic extract of propolis (EEP) against 38 clinical
isolates of H. pylori was evaluated by using the agar-well diffusion method.
Ethanol was used as a control. In addition, the effect of propolis on the
growth of 26 H. pylori and 18 Campylobacter strains was tested by the disc
diffusion method. Mean diameters of H. pylori growth inhibition by the agar-well
diffusion method, using 30, 60 or 90 microl EEP or 30 microl ethanol per well,
were 17.8, 21.2, 28.2 and
PMID: 12721318 [PubMed - indexed for MEDLINE]
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20:
J
Ethnopharmacol. 2003 May;86(1):69-73. |
Antimicrobial activity of propolis samples from two different regions of
Kartal M, Yildiz S, Kaya S, Kurucu S, Topcu G.
Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, 06100
Ankara, Turkey. kartal@pharmacy.ankara.edu.tr
Antimicrobial activity of two propolis samples from Kazan and Marmaris regions
in
PMID: 12686444 [PubMed - indexed for MEDLINE]
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21:
Phytother
Res. 2003 Mar;17(3):285-9. |
Brazilian propolis: physicochemical properties, plant origin and
antibacterial activity on periodontopathogens.
Santos FA, Bastos EM, Maia AB, Uzeda M, Carvalho MA, Farias LM, Moreira ES.
Departamento
de Microbiologia, Universidade Federal de Minas Gerais, Brazil.
Propolis samples collected in the dry and rainy seasons, from an experimental
apiary located in a cerrado vegetation region in
PMID: 12672164 [PubMed - indexed for MEDLINE]
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22:
Pol
J Vet Sci. 2002;5(4):223-5. |
Investigation on the inhibition of Campylobacter jejuni growth with the
applications of some preservatives, medicines, herbs and herb preparations.
Uradzinski J, Szteyn J, Kafel S.
Department of Animal Products Hygiene, Faculty of Veterinary Medicine,
University of Warmia and Mazury, Oczapowskiego 14, 10-719 Olsztyn, Poland.
janurad@moskit.uwm.edu.pl
The aim of this study was to determine the influence of chosen preservatives,
medicines, herbs and herb preparations on 39 Campylobacter jejuni strains,
which were isolated from fresh poultry carcasses. De-Nol and ventrisol were
used in the original concentration. Propolis, propolan, artecholin and aukalen
were of pharmacies origin. The rest of substances examined were 10% water
solutions. Out of 11 substances examined, potassium sorbate, sodium benzoate,
De-Nol and ventrisol exerted the strongest inhibitory action on Campylobacter
jejuni.
PMID: 12512554 [PubMed - indexed for MEDLINE]
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23:
Fitoterapia.
2002 Nov;73 Suppl 1:S1-6. |
Propolis, an old remedy used in modern medicine.
Castaldo S, Capasso F.
Department of I.N.P.S. of Naples, via Medina 63, Naples, Italy.
Propolis is one of the few natural remedies that has maintained its popularity
over a long period of time. The pharmacologically active molecules in the
propolis are flavonoids and phenolic acids and their esters. These components
have multiple effects on bacteria, fungi and viruses. In addition, propolis and
its components have anti-inflammatory and immunomodulatory activities.
Moreover, propolis has been shown to lower blood pressure and cholesterol
levels. However, clinical studies to substantiate these claims are required.
Publication Types:
·
Review
PMID: 12495704 [PubMed - indexed for MEDLINE]
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24:
Pol
J Vet Sci. 2002;5(3):197-202. |
The use of some immunomodulators and non-antibiotic drugs in a
prophylaxis and treatment of mastitis.
Malinowski E.
Department of Pathophysiology of Reproduction and Mammary Gland. National
Veterinary Research Institute, Powstancow Wikp, 10, 85-090
Antibiotics are widely used in treatment and prophylaxis of mastitis, but their
antibacterial and therapeutic efficacy continues to decrease. New methods of
prophylaxis of mastitis with the use of vaccines and biological response
modifiers are reviewed. Prophylactic activity of staphylococcal vaccines should
be investigated in the future because of difficulties in successful treatment
of infections caused by these organisms. Vaccination with J5 bacterin (0111:B4)
reduced duration of IMI and local signs of clinical coliform-mastitis. Some
immunomodulators proved to be effective in treatment of mastitis during
lactating period. Promising results were obtained with the use of giseng
saponin, herbal gel, herbal extracts, propolis, lysosubtilin, antibacterial
proteins, and lysozyme dimer especially.
Publication Types:
·
Review
PMID: 12448082 [PubMed - indexed for MEDLINE]
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25:
Z
Naturforsch [C]. 2002 Mar-Apr;57(3-4):395-402. |
Egyptian propolis: 3. Antioxidant, antimicrobial activities and chemical
composition of propolis from reclaimed lands.
Hegazi AG, Abd El Hady FK.
Department of Parasitology, National Research Center, Dokki, Giza, Egypt.
ahmedgaffer@mailer.suc.eun.eg
The free radical scavenging effect of two propolis samples collected from
reclaimed land,
PMID: 12064746 [PubMed - indexed for MEDLINE]
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26:
Z
Naturforsch [C]. 2002 Mar-Apr;57(3-4):386-94. |
Egyptian propolis: 2. Chemical composition, antiviral and antimicrobial
activities of
Abd El Hady FK, Hegazi AG.
Department of Chemistry of Natural Products, National Research Center, Dokki,
Giza, Egypt.
Three propolis samples from East Nile Delta,
PMID: 12064745 [PubMed - indexed for MEDLINE]
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27:
J Oral
Sci. 2002 Mar;44(1):41-8. |
Effect of commercial ethanol propolis extract on the in vitro growth of
Candida albicans collected from HIV-seropositive and HIV-seronegative Brazilian
patients with oral candidiasis.
Martins RS, Pereira ES Jr,
Lima SM, Senna MI, Mesquita RA, Santos VR.
Department
of Clinical Pathology and Surgery, School of Dentistry, Minas Gerais Federal
University, Belo Horizonte, Brazil.
The present study assessed the susceptibility of Candida albicans strains,
collected from HIV-positive patients with oral candidiasis, to a commercial 20%
ethanol propolis extract (EPE) and compare it to the inhibitory action of the
standardized antifungal agents nystatin (NYS), clotrimazole (CL), econazole
(EC), and fluconazole (FL). Twelve C. albicans strains collected from
HIV-positive patients with oral candidiasis were tested. The inhibition zones
were measured with a pachimeter and the results are reported as means and
standard deviation (M +/- SD). Data were analyzed statistically by the
non-parametric Kruskal-Wallis test. EPE inhibited all the C. albicans strained
tested. No significant difference was observed between the results obtained
with NYS and EPE, while significant differences were observed between EPE and
other antifungals. The C. albicans strains tested showed resistance to the
remaining antifungal agents. The propolis extract used in this study inhibited
the in vitro growth of C. albicans collected from HIV-seropositive Brazilian
patients, creating/forming inhibition zones like those ones formed by NYS. This
fact suggests that commercial EPE could be an alternative medicine in the
treatment of candidiasis from HIV-positive patients. However, in vivo studies
of the effect of EPE are needed to determine its possible effects on the oral
mucosa.
PMID: 12058869 [PubMed - indexed for MEDLINE]
|
28:
J
Ethnopharmacol. 2002 Apr;80(1):1-7. |
Antibacterial activity of Brazilian propolis and fractions against oral
anaerobic bacteria.
Santos FA, Bastos EM, Uzeda M, Carvalho MA, Farias LM, Moreira ES, Braga FC.
Departamento de Microbiologia, Laboratorio de Biologia de Microrganismos,
Instituto de Ciencias Biologicas da Universidade Federal de Minas Gerais, Caixa
Postal 486, Avenida
Propolis
collected from a cerrado area in
PMID: 11891080 [PubMed - indexed for MEDLINE]
|
29: Z Naturforsch [C]. 2001
Nov-Dec;56(11-12):1112-5. |
Antibacterial activity and chemical composition of Turkish propolis.
Keskin N, Hazir S, Baser KH, Kurkcuoglu M.
The antibacterial activities of propolis samples have been examined in vitro,
according to the principles accepted for the determination of a similar
activity of antibiotics with the use of solid and liquid media. It has been
found that propolis extracts showed antibacterial activity through a range of
commonly encountered gram positive cocci (S. aureus, beta hem. Streptococus),
but had weak activity against gram negative bacteria (E. coli, P. aeruginosa).
GC/MS analysis showed that propolis samples contain a variety of chemical
compounds including aromatic compounds, fatty acid esters and sesquiterpenes.
PMID: 11837665 [PubMed - indexed for MEDLINE]
|
30: Z Naturforsch [C]. 2001
Jul-Aug;56(7-8):593-6. |
New bioactive chalcones in propolis from El Salvador.
Popova M, Bankova V, Spassov S, Tsvetkova I, Naydenski C, Silva MV, Tsartsarova M.
2',3'-Dihydroxy-4,4'-dimethoxychalcone (1) and
2',3',4-trihydroxy-4'-methoxy-chalcone, two new chalcones, were isolated from
propolis from
PMID: 11531095 [PubMed - indexed for MEDLINE]
|
31:
Anticancer
Res. 2001 May-Jun;21(3B):1665-71. |
PM-
Luo J, Soh JW, Xing WQ, Mao Y, Matsuno T, Weinstein IB.
Herbert
Irving Comprehensive Cancer Center, Columbia Presbyterian Medical Center,
College of Physicians and Surgeons, Columbia University, New York, NY 10032,
USA.
Propolis has numerous biologic activities including antibiotic, antifungal,
antiviral and anti-inflammatory properties. Several components isolated from
propolis have been shown to have anticancer activity. This study demonstrates
that the compound PM-3
(3-[2-dimethyl-8-(3-methyl-2-butenyl)benzopyran]-6-propenoic acid) isolated
from Brazilian propolis markedly inhibits the growth of MCF-7 human breast
cancer cells. This effect was associated with inhibition of cell cycle
progression and induction of apoptosis. Treatment of MCF-7 cells with PM-3
arrested cells in the G1 phase and resulted in a decrease in the protein levels
of cyclin D1 and cyclin E. PM-3 also inhibited the expression of cyclin D1 at
the transcriptional level when examined in cyclin D1 promoter luciferase
assays. Induction of apoptosis by PM-3 occurred within 48 hours after treatment
of MCF-7 cells. The MCF-7 treated cells also displayed a decrease in the level
of the estrogen receptor (ER) protein and inhibition of estrogen response element
(ERE) promoter activity. Therefore, PM-3 merits further investigation with
respect to breast cancer chemoprevention or therapy.
PMID: 11497245 [PubMed - indexed for MEDLINE]
|
32: Z Naturforsch [C]. 2001
Jan-Feb;56(1-2):82-8. |
Egyptian propolis: 1-antimicrobial activity and chemical composition of
Hegazi AG, El Hady FK.
Department of Parasitology, National Research Center, Dokki, Giza, Egypt.
ahmedgaffer@mailer.suc.eun.eg
The antimicrobial activity of four propolis samples collected from
PMID: 11302219 [PubMed - indexed for MEDLINE]
|
33:
Phytomedicine.
2001 Jan;8(1):16-23. |
Hepatoprotective and anti-Helicobacter pylori activities of constituents
from Brazilian propolis.
Banskota AH, Tezuka Y, Adnyana IK, Ishii E, Midorikawa K, Matsushige K, Kadota S.
Department
of Natural Products Chemistry, Institute of Natural Medicine, Toyama Medical
and Pharmaceutical University, Japan.
Propolis is a resinous hive product collected by honeybees from various plant
sources. It is extensively used in food, beverage and in folk medicine for
treating various ailments and reported to have broad spectrum of biological
activities. The hepatoprotective activity of propolis and constituents from its
MeOH extract belonging to various classes were tested on D-galactosamine
(D-GalN)/tumor necrosis factor-alpha (TNF-alpha)-induced cell death in primary
cultured mouse hepatocytes. The result indicated that hepatoprotective activity
of alcoholic extract of tropical Brazilian propolis is mainly due to phenolic
compounds including flavonoids. All the four isolated flavonoids possessed
stronger inhibitory activity (IC50, < 25 microM) than silibinin (IC50, 39.6
microM) on TNF-alpha-induced cell death. The labdane-type diterpenes isolated
from the MeOH extract also exhibited significant hepatoprotective activity in
the same experimental model. Moreover, the labdane-type diterpenes and some of
the prenylated phenolic compounds possessed antibacterial activity against
Helicobacter pylori.
PMID: 11292234 [PubMed - indexed for MEDLINE]
|
34:
J
Ethnopharmacol. 2001 Feb;74(2):105-12. |
Phenolic compounds from Brazilian propolis with pharmacological
activities.
Marcucci MC, Ferreres F, Garcia-Viguera C,
Bankova VS, De Castro SL, Dantas AP, Valente PH, Paulino N.
Laboratorio de Fitoquimica, CEBAS (CSIC) Apdo Correos 4195, 30080, Murcia,
Spain. mcmarcucci@hotmail.com
Four compounds were isolated from Brazilian propolis. They are identified as:
(1) 3-prenyl-4-hydroxycinnamic acid (PHCA), (2)
2,2-dimethyl-6-carboxyethenyl-2H-1-benzopyrane (DCBEN), (3) 3,5-diprenyl-4-hydroxycinnamic
acid (DHCA), and (4) 2,2-dimethyl-6-carboxyethenyl-8-prenyl-2H-1-benzopyran
(DPB). The
structures of the compounds were determined by MS and NMR techniques. All
compounds were assayed against Trypanosoma cruzi and the bacteria Escherichia
coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus faecalis.
Compounds (1) to (4) were active against T. cruzi. Except (1), all compounds
presented activity against the bacteria tested. When compounds (1)-(3) were
tested in the guinea pig isolated trachea, all induced a relaxant effect
similar to propolis extract.
PMID: 11167028 [PubMed - indexed for MEDLINE]
|
35: Z Naturforsch [C]. 2000
Sep-Oct;55(9-10):790-3. |
Propolis from the Mediterranean region: chemical composition and
antimicrobial activity.
Velikova M, Bankova V, Sorkun K, Houcine S, Tsvetkova I, Kujumgiev A.
The chemical composition of propolis from
PMID: 11098832 [PubMed - indexed for MEDLINE]
|
36:
Fitoterapia.
2000 Dec;71(6):693-6. |
Antibacterial ent-kaurene from Brazilian propolis of native stingless
bees.
Velikova M, Bankova V, Tsvetkova I, Kujumgiev A, Marcucci MC.
Three ent-kaurene diterpenoids, not previously described as constituents of
propolis, were isolated from a sample collected by Brazilian native bees
Melipona quadrifasciata anthidioides. One of them, kaurenoic acid, as well as
the total extract, displayed moderate antibacterial activity.
PMID: 11077178 [PubMed - indexed for MEDLINE]
|
37: J Altern Complement Med. 2000 Oct;6(5):383-9. |
Detection of antimicrobials in bee products with activity against
viridans streptococci.
Tichy J, Novak J.
Department of Microbiology, University of Alabama at Birmingham, 35294, USA.
OBJECTIVES: Bee products have been studied extensively for their healing
properties and have become part of cosmetic preparations and folk medicine. The
major objective of this study was to examine the presence of antimicrobials in
various bee products. DESIGN: Propolis, honeycomb lids, pollen, honeycombs, and
honey were screened for antimicrobial compounds. Viridans streptococci were
used as indicator strains. Ethanol extracts were applied onto paper disks, dried,
and put on the surface of nutrient agar plates with the overlay containing
viridans streptococci. The plates were then incubated and evaluated the next
day for the presence of inhibition zones. The size of the inhibition zone
represented a quantitative measure of antimicrobial activity in a sample.
Thin-layer chromatography was used for separation of compounds in the samples
and biodetection-an overlay with indicator strain-identified the antimicrobial
compounds by formation of inhibition zones. RESULTS: Ethanol extracts of
propolis and honeycomb lids, as well as honey containing honeycomb lids
contained a mixture of antimicrobial compounds in various amounts. Thin-layer
chromatography experiments with two different solvent systems differing in polarity
suggested that major antimicrobials present in the samples prepared from
honeycomb lids, honeycombs, pollen, and propolis have similar properties. These
active compounds were not extremely hydrophobic. CONCLUSIONS: Extracts from the
tested samples of bee products exhibited antimicrobial properties at various
levels depending on the sample and bacterial species used for testing. Using
chromatographic techniques, we demonstrated similar properties of the active
compounds in various active samples. In conclusion, our results suggest that
honey containing honeycomb lids may be a beneficial food supplement because of
the presence of antibacterial compounds.
PMID: 11059500 [PubMed - indexed for MEDLINE]
|
38:
J
Ethnopharmacol. 2000 Nov;73(1-2):243-9. |
Seasonal effect on Brazilian propolis antibacterial activity.
Sforcin JM, Fernandes A Jr, Lopes CA, Bankova V, Funari SR.
Department of Microbiology and Immunology, Biosciences Institute, UNESP,
18618-000, SP, Botucatu, Brazil.
The behavior of microorganisms towards the antibiotic action of propolis has
been widely investigated. Since reports dealing with seasonal effect on
propolis activity are not available, this assay was carried out aiming to
observe the in vitro antimicrobial activity of propolis, collected during the
four seasons, on bacterial strains isolated from human infections. Dilution of
ethanolic extract of propolis (EEP) in agar was the method performed, with serial
concentrations ranging from 0.4 to 14.0% (% v/v). The behavior of some bacteria
was analysed according to the incubation period in medium plus propolis, and
the survival curve was plotted. It was verified that the growth of
Gram-positive bacteria is inhibited by low propolis concentrations (0.4%)
whereas Gram-negative bacteria were less susceptible to this substance, the
minimal inhibitory concentration ranging from 4.5 to 8.0%. There was no
significant difference with regards to the seasonal effect on the survival
curve of Staphylococcus aureus and Escherichia coli; after incubation with
propolis, there was an efficient antimicrobial action, mainly towards
Gram-positive bacteria.
PMID: 11025162 [PubMed - indexed for MEDLINE]
|
39:
Zentralbl
Chir. 2000;125 Suppl 1:84-6. |
[From the history of wound care]
[Article in German]
Benedum J.
Institut fur Geschichte der Medizin,
Wound care in ancient times was based on many techniques: Bandages soaked with
antibiotics, Sutures continuous or in separate stitches, apply of poultices
around the wounds, honey and propolis as antibiotics in the treatment of
wounds, surgical drainage of pus with a piece of tin pipe etc. The oldest wound
clamp is shown with the jaws of ants holding together the edges of a wound.
Finally are discussed the cauterization and the principles of Antisepsis and
Asepsis.
Publication Types:
PMID: 10929654 [PubMed - indexed for MEDLINE]
|
40: Z Naturforsch [C]. 2000
Jan-Feb;55(1-2):70-5. |
Chemical composition and antimicrobial activity of European propolis.
Hegazi AG, Abd El Hady FK, Abd Allah FA.
Department of Parasitology, National Research Center, Dokki, Giza, Egypt.
ahmedgaffer@frcu.eun.eg
Three propolis samples from
PMID: 10739103 [PubMed - indexed for MEDLINE]
|
41:
Arch
Oral Biol. 2000 Feb;45(2):141-8. |
In vitro antimicrobial activity of propolis and Arnica
Koo H, Gomes BP, Rosalen PL, Ambrosano GM, Park YK, Cury JA.
Arnica and propolis have been used for thousands of years in folk medicine for
several purposes. They possess several biological activities such as
anti-inflammatory, antifungal, antiviral and tissue regenerative, among others.
Although the antibacterial activity of propolis has already been demonstrated,
very few studies have been done on bacteria of clinical relevance in dentistry.
Also, the antimicrobial activity of Arnica has not been extensively
investigated. Therefore the aim here was to evaluate in vitro the antimicrobial
activity, inhibition of adherence of mutans streptococci and inhibition of
formation of water-insoluble glucan by Arnica and propolis extracts. Arnica
PMID: 10716618 [PubMed - indexed for MEDLINE]
|
42:
Ophthalmic
Res. 2000 Jan-Feb;32(1):13-8. |
The effect of propolis extract in experimental chemical corneal injury.
Ozturk F, Kurt E, Cerci M, Emiroglu L, Inan U, Turker M, Ilker S.
Department of Ophthalmology, Celal Bayar University, Faculty of Medicine,
Manisa, Turkey. fozturk@bayar.edu.tr
PURPOSE: To investigate the effect of propolis, a natural resin produced by
honeybees, in the treatment of alkali-injured rabbit eyes. METHOD: A corneal
alkali burn was induced by applying filter paper immersed in 1 N NaOH on the
central axis of the right corneas of 24 rabbits for 30 s. The animals were
divided into three treatment groups: group 1 (control) was given 0.3%
tobramycin and phosphate-buffered solution; group 2 was treated with antibiotic
coverage and topical 1% ethanolic extract of propolis; group 3 received
antibiotic coverage and topical 1% dexamethasone. The dexamethasone-treated
group was maintained as the positive control. Drugs were instilled 4 times a
day for 7 days. The corneal inflammation was evaluated by calculating the
average inflammatory index obtained from clinical observation of the ciliary
hyperemia, central and peripheral corneal edema at 24 h, 48 h, on day 5 and day
7, before sacrificing the animals. Then, the corneas underwent routine
histological examination. RESULTS: The effects of dexamethasone and propolis on
healing of injured corneas were similar (p>0.05) and significantly better
than controls at 24 h (p<0.01, p< 0.05, respectively), and on day 7
(p<0.05) with respect to the inflammatory index. On histological
observation, inflammatory cell infiltration was lower as compared to control in
both the dexamethasone and propolis groups (p<0.001) and similar with each
other (p>0.05). CONCLUSIONS: Our study shows that propolis has an
anti-inflammatory effect comparable to dexamethasone in chemical corneal
injury. Copyright 2000 S. Karger AG,
PMID: 10657750 [PubMed - indexed for MEDLINE]
|
43:
J
Ethnopharmacol. 1999 Dec 15;68(1-3):97-102. |
Screening of antibacterial activity of Amaicha del Valle (
Nieva Moreno MI,
Isla MI, Cudmani NG, Vattuone MA, Sampietro AR.
Catedra de Fitoquimica, Instituto de Estudios Vegetales, Facultad de
Bioquimica, Quimica y Farmacia, Universidad Nacional de Tucuman, Miguel de
Tucuman, Argentina.
Propolis is
extensively used in Argentine folk medicine. Alcoholic extracts of propolis
from four localities of Amaicha del Valle (El Paraiso,
PMID: 10624867 [PubMed - indexed for MEDLINE]
|
44: Z Naturforsch [C]. 1999
Jul-Aug;54(7-8):549-53. |
Synergism between ethanolic extract of propolis (EEP) and
anti-tuberculosis drugs on growth of mycobacteria.
Scheller S, Dworniczak S, Waldemar-Klimmek K, Rajca M, Tomczyk A, Shani J.
Department of Microbiology and Immunology, Silesian Academy of Medicine,
Zabrze-Rokitnica, Poland.
Ethanolic extract of propolis exerts a strong anti-bacterial activity, in
addition to antifungal, antiviral and antiprotozoal properties. In previous
studies from these laboratories we have demonstrated that the intensity of the
bactericidal activity of EEP is correlated with the virulence of the
mycobacteria tested, and that EEP has a synergistic effect with antibiotics on
growth of staphylococcus aureus. In the present study we investigated whether
the same synergism and correlation exists between EEP and some
anti-tuberculosis drugs on tuberculosis mycobacteria with different degrees of
virulence. Six standard strains and 11 wild strains of mycobacteria were
exposed for 30 days to EEP, with or without streptomycin, rifamycin, isoniazid
or ethambutol. Out of the 17 strains, 8 were resistant to at least two standard
antibiotics, and were considered "multi-resistant strains". The rest
were either susceptible or resistant to only one of the antimycobacterial
drugs. Antagonism was recorded only in one case, when Staphylococcus aureus
were treated with a mixture of EEP and ethambutol, suggesting that a chemical
bond could have been formed between this anti-tuberculosis antibiotic and one
of the active components of the ethanol extract of propolis.
PMID: 10488563 [PubMed - indexed for MEDLINE]
|
45: Z Naturforsch [C]. 1999
May-Jun;54(5-6):401-5. |
Phytochemical evidence for the plant origin of Brazilian propolis from
Sao Paulo state.
Bankova V, Boudourova-Krasteva G, Sforcin JM, Frete X, Kujumgiev A, Maimoni-Rodella R, Popov S.
Propolis and plant secretions from three species, most frequently mentioned as
botanical sources of the bee glue in Brazil (Baccharis dracunculifolia,
Araucaria angustifolia and Eucalyptus citriodora) have been investigated using
GC-MS. Based on chemical evidence, B. dracunculifolia was shown to be the main
propolis source in Sao Paulo state. The antibacterial and antifungal activities
of all four materials were also tested, the most active being propolis and
Baccharis leaf exudate.
PMID: 10431391 [PubMed - indexed for MEDLINE]
|
46:
J Nat
Prod. 1999 Jul;62(7):1013-5. |
A polyisoprenylated benzophenone from Cuban propolis.
Rubio OC, Cuellar Cuellar A,
Rojas N, Castro HV, Rastrelli L, Aquino R.
Institute
for Pharmacy and Food (IFAL), University of
A novel polyisoprenylated benzophenone (1) has been isolated from an ethanol
extract of Cuban propolis. Its structure has been determined using high-field
2D NMR techniques. Compound 1 showed significant antimicrobial and antifungal
activity against a variety of bacteria and yeasts.
PMID: 10425129 [PubMed - indexed for MEDLINE]
|
47: Int J Mol Med. 1999 Jul;4(1):29-32. |
Apoptosis induced by propolis in human hepatocellular carcinoma cell
line.
Choi YH, Lee WY, Nam SY, Choi KC, Park YE.
Department of Pathology,
Propolis has been reported to exhibit a wide spectrum of activities including
antibiotic, antiviral, anti-inflammatory, immunostimulatory and tumor
carcinostatic properties. We showed propolis induced apoptosis in a human
hepatoma cell line (SNU449) by FITC-Annexin V/PI staining. We also compared the
apoptosis inducing effect between Korean and Commercial (Sigma # p-1010)
propolis. There was no difference on apoptosis between them.
PMID: 10373633 [PubMed - indexed for MEDLINE]
|
48:
J
Ethnopharmacol. 1999 Mar;64(3):235-40. |
Antibacterial, antifungal and antiviral activity of propolis of
different geographic origin.
Kujumgiev A, Tsvetkova I, Serkedjieva Y, Bankova V, Christov R, Popov S.
Propolis samples from different geographic origins were investigated for their
antibacterial (against Staphylococcus aureus and Escherichia coli), antifungal
(against Candida albicans) and antiviral (against Avian influenza virus)
activities. All samples were active against the fungal and Gram-positive
bacterial test strains, and most showed antiviral activity. The activities of
all samples were similar in spite of the differences in their chemical
composition. In samples from the temperate zone, flavonoids and esters of
phenolic acids are known to be responsible for the above mentioned activities
of bee glue; tropical samples did not contain such substances but showed
similar activities. Obviously, in different samples, different substance
combinations are essential for the biological activity of the bee glue. It
seems that propolis has general pharmacological value as a natural mixture and
not as a source of new powerful antimicrobial, antifungal and antiviral
compounds.
PMID: 10363838 [PubMed - indexed for MEDLINE]
|
49:
Food
Chem Toxicol. 1998 Apr;36(4):347-63. |
Review of the biological properties and toxicity of bee propolis
(propolis).
Burdock GA.
Burdock and Associates, Vero Beach, FL 32963, USA.
Propolis is a multifunctional material used by bees in the construction and
maintenance of their hives. Use of propolis by humans has a long history,
predated only by the discovery of honey. Use of products containing propolis
have resulted in extensive dermal contact and it is now increasingly being used
a dietary supplement. Unlike many 'natural' remedies, there is a substantive
database on the biological activity and toxicity of propolis indicating it may
have many antibiotic, antifungal, antiviral and antitumour properties, among
other attributes. Although reports of allergic reactions are not uncommon, propolis
is relatively non-toxic, with a no-effect level (NOEL) in a 90-mouse study of
1400 mg/kg body weight/day.
Publication Types:
·
Review
PMID: 9651052 [PubMed - indexed for MEDLINE]
|
50:
Curr
Microbiol. 1998 Jan;36(1):24-8. |
Antimicrobial activity of propolis on oral microorganisms.
Park YK, Koo MH, Abreu JA, Ikegaki M, Cury JA, Rosalen PL.
Formation of dental caries is caused by the colonization and accumulation of
oral microorganisms and extracellular polysaccharides that are synthesized from
sucrose by glucosyltransferase of Streptococcus mutans. The production of
glucosyltransferase from oral microorganisms was attempted, and it was found
that Streptococcus mutans produced highest activity of the enzyme. Ethanolic
extracts of propolis (EEP) were examined whether EEP inhibit the enzyme
activity and growth of the bacteria or not. All EEP from various regions in
PMID: 9405742 [PubMed - indexed for MEDLINE]
|
51:
Microbiol
Res. 1997 Sep;152(3):239-46. |
Antimicrobial action of propolis and some of its components: the effects
on growth, membrane potential and motility of bacteria.
Mirzoeva OK, Grishanin RN, Calder PC.
Department of Biochemistry, University of Oxford, United Kingdom.
The effect of the natural bee product propolis on the physiology of
microorganisms was investigated using B. subtilis, E. coli and R. sphaeroides.
An ethanolic extract of propolis had a bactericidal effect caused by the
presence of very active, but labile, ingredients. The exact bactericidal effect
of propolis was species dependent: it was effective against gram-positive and
some gram-negative bacteria. Propolis and some of its cinnamic and flavonoid
components were found to uncouple the energy transducing cytoplasmic membrane
and to inhibit bacterial motility. These effects on the bioenergetic status of
the membrane may contribute to the antimicrobial action of propolis and its
observed synergism with selected antibiotics.
PMID: 9352659 [PubMed - indexed for MEDLINE]
|
52: Z Naturforsch [C]. 1996
May-Jun;51(5-6):277-80. |
Antibacterial diterpenic acids from Brazilian propolis.
Bankova V, Marcucci MC, Simova S, Nikolova N, Kujumgiev A, Popov S.
Four labdane-type diterpenic acids and syringaldehyde were isolated and
identified from Brazilian propolis. All the compounds exhibit antibacterial
activity. The diterpenes, found for the first time in propolis, are typical for
some Araucaria species and thus indicate a possible plant source of Brazilian
propolis.
PMID: 8663896 [PubMed - indexed for MEDLINE]
|
53:
Z
Naturforsch [C]. 1995 Mar-Apr;50(3-4):167-72. |
Chemical composition and antibacterial activity of Brazilian propolis.
Bankova V, Christov R, Kujumgiev A, Marcucci MC, Popov S.
Four samples of Brazilian propolis were investigated by GC/MS of different
fractions. 32 volatile compounds, (10 of them new for propolis), as well as 12
more polar compounds (one of them new for propolis) were identified.
Antibacterial activity was found in some propolis fractions.
PMID: 7766255 [PubMed - indexed for MEDLINE]
|
54:
Planta
Med. 1994 Jun;60(3):222-7. |
Electron microscopic and microcalorimetric investigations of the
possible mechanism of the antibacterial action of a defined propolis
provenance.
Takaisi-Kikuni NB, Schilcher H.
Department de Microbiologie, Faculte de Pharmacie, Universite de Kinshasa,
Zaire.
Microcalorimetric and electron microscopic studies on the mode of the
antibacterial action of propolis were performed on Streptococcus agalactiae. It
was shown that propolis inhibits bacterial growth by preventing cell division,
thus resulting in the formation of pseudo-multicellular streptococci. In
addition, propolis disorganized the cytoplasm, the cytoplasmic membrane, and
the cell wall, caused a partial bacteriolysis, and inhibited protein synthesis.
It was evident that the mechanism of action of propolis on bacterial cells is
complex and a simple analogy cannot be made to the mode of action of any
classic antibiotics.
PMID: 8073087 [PubMed - indexed for MEDLINE]
|
55: Z Naturforsch [C]. 1994
Jan-Feb;49(1-2):39-43. |
Biochemical activities of propolis-extracts. III. Inhibition of
dihydrofolate reductase.
Strehl E, Volpert R, Elstner EF.
Institut fur Botanik und Mikrobiologie, Biochemisches Labor, Technische
Universitat Munchen.
Ethanolic and aqueous extracts of the natural compound PROPOLIS indicate substantial
antiinflammatory functions as well as antibiotic activities in vitro and in
vivo. The exact mode of physiological or biochemical mechanisms responsible for
the medical effects, however, is all but clear. The standardization on the
basis of quantitative determination of prominent components of these extracts
have been substituted recently by simple biochemical model reactions including
photodynamic properties. In this communication we report on the inhibitory
activity of an aqueous extract of propolis on the enzyme dihydrofolate
reductase. This activity may at least partially be due to the content of
caffeic acid, as revealed by HPLC chromatography and comparative activity tests
of representative ingredients of the propolis extract. This result may explain
some of the protective functions of propolis, similar to those shown for
several "non-steroidal antiinflammatory drugs", NSAIDs.
PMID: 8148008 [PubMed - indexed for MEDLINE]
|
56:
Pharmazie.
1993 Oct;48(10):785-6. |
Antibacterial activity of propolis, some of its components and their
analogs.
Kujumgiev A, Bankova V, Ignatova A, Popov S.
PMID: 8265716 [PubMed - indexed for MEDLINE]
|
57:
Arzneimittelforschung.
1993 Aug;43(8):921-3. |
Bactericidal effect of propolis in vitro against agents causing upper
respiratory tract infections.
Focht J, Hansen SH, Nielsen JV, van den Berg-Segers A, Riezler R.
Bioscientia, Institute for Laboratory Medicine,
Propolis is a natural product of bees which exhibits an antimicrobial effect.
In the study the existence of a bactericidal effect against several strains
isolated from patients with infections in their upper respiratory tracts is
demonstrated. In light of the use of propolis as a therapeutic agent in natural
medicine for common colds and inflammatory processes this effect is discussed.
PMID: 8216454 [PubMed - indexed for MEDLINE]
|
58:
Arzneimittelforschung.
1993 May;43(5):607-9. |
Synergistic effect of ethanolic extract of propolis and antibiotics on
the growth of staphylococcus aureus.
Krol W, Scheller S, Shani J, Pietsz G, Czuba Z.
Department of Microbiology and Immunology, Silesian School of Medicine,
Zabrze-Rokitnica, Poland.
Ethanolic extract of propolis (EEP), known to possess marked antibacterial
activity, was incubated with 8 different common antibiotics in culture medium
containing a fixed amount of a standard strain of Staphylococcus aureus. The
antibiotic compounds used were: penicillin G, doxycycline, streptomycin,
cloxacillin, chloramphenicol, cefradine, ampicillin and polymyxin B. They were used
in varying levels, ranging between 0.000005-125.0 micrograms/ml or units, resp.
Firstly, their minimal inhibitory concentrations were established in the
absence of EEP, than EEP was added in concentrations up to 600 micrograms/ml.
EEP had a marked synergistic effect on the antibacterial activity of
streptomycin and cloxacillin, and a moderate synergistic effect on the others,
except ampicillin.
PMID: 8329008 [PubMed - indexed for MEDLINE]
|
59:
Chem
Biol Interact. 1992 Nov 16;84(3):277-90. |
Effect of caffeic acid esters on carcinogen-induced mutagenicity and
human colon adenocarcinoma cell growth.
Rao CV, Desai D, Kaul B, Amin S, Reddy BS.
Division of Nutritional Carcinogenesis, American Health Foundation, Valhalla,
New York.
Propolis, a honey bee hive product, is thought to exhibit a broad spectrum of
activities including antibiotic, antiviral, anti-inflammatory and tumor growth
inhibition; some of the observed biological activities may be due to caffeic
acid (cinnamic acid) esters that are present in propolis. In the present study
we synthesized three caffeic acid esters, namely methyl caffeate (MC),
phenylethyl caffeate (PEC) and phenylethyl dimethylcaffeate (PEDMC) and tested
them against the 3,2'-dimethyl-4-aminobiphenyl, (DMAB, a colon and mammary
carcinogen)-induced mutagenicity in Salmonella typhimurium strains TA 98 and TA
100. Also, the effect of these agents on the growth of human colon
adenocarcinoma, HT-29 cells and activities of ornithine decarboxylase (ODC) and
protein tyrosine kinase (PTK) was studied. Mutagenicity was induced in
Salmonella typhimurium strains TA 98 and TA 100 plus S9 activation using 5 and
10 micrograms DMAB and antimutagenic activities of 0-150 microM MC, 0-60 microM
PEC and 0-80 microM PEDMC were determined. The results indicate that MC, PEC
and PEDMC were not mutagenic in the Salmonella tester system. DMAB-induced
mutagenicity was significantly inhibited with 150 microM MC, 40-60 microM PEC
and 40-80 microM PEDMC in both tester systems. Treatment of HT-29 colon
adenocarcinoma cells with > 150 microM MC, 30 microM PEC and 20 microM PEDMC
significantly inhibited the cell growth and syntheses of RNA, DNA and protein.
ODC and PTK activities were also inhibited in HT-29 cells treated with
different concentrations of MC, PEC and PEDMC. These results demonstrate that
caffeic acid esters which are present in Propolis possess chemopreventive
properties when tested in short-term assay systems.
PMID: 1423745 [PubMed - indexed for MEDLINE]
|
60:
J
Ethnopharmacol. 1991 Oct;35(1):77-82. |
Antibacterial, antifungal, antiamoebic, antiinflammatory and antipyretic
studies on propolis bee products.
Dobrowolski JW,
Vohora SB, Sharma K, Shah SA, Naqvi SA, Dandiya PC.
PMID: 1753797 [PubMed - indexed for MEDLINE]
|
61:
Zhongguo
Zhong Yao Za Zhi. 1991 Aug;16(8):481-2, 512. |
[Isolation and identification of antibiotic constituents of propolis
from
[Article in Chinese]
Qiao Z, Chen R.
Sinapic acid, isoferulic acid, caffeic acid and chrysin were isolated from the
alcoholic extraction of propolis and identified by spectrometric methods. The first
three compounds were shown with inhibitive effect of against Staphylococcus
aureus, while chrysin was ineffective.
PMID: 1804186 [PubMed - indexed for MEDLINE]
|
62:
J R
Soc Med. 1990 Mar;83(3):159-60. |
Antibacterial properties of propolis (bee glue).
Grange JM, Davey RW.
Department of Microbiology, National Heart & Lung Institute, London.
Propolis (bee glue) was found to have antibacterial activity against a range of
commonly encountered cocci and Gram-positive rods, including the human tubercle
bacillus, but only limited activity against Gram-negative bacilli. These
findings confirm previous reports of antimicrobial properties of this material,
possibly attributable to its high flavonoid content.
Publication Types:
·
Review
PMID: 2182860 [PubMed - indexed for MEDLINE]
|
63:
Microbios.
1990;62(250):19-22. |
Antibiotic activity of natural products: 1. Propolis.
Brumfitt W, Hamilton-Miller JM, Franklin I.
Department of Medical Microbiology, Royal Free Hospital, Hampstead, London,
Great Britain.
Material extracted from propolis (bee glue) by alkaline aqueous solvents or
organic solvents showed weak inhibitory activity in vitro against certain
species of Gram-positive bacteria. No antimicrobial activity was detected in
urine from three volunteers who had taken 500 mg propolis three times a day for
3 days.
PMID: 2110610 [PubMed - indexed for MEDLINE]
|
64:
Przegl
Dermatol. 1985 May-Jun;72(3):253-6. |
[Role of allergens causing skin lesions in humans in the development of
allergy in dogs. IV. Contact allergens]
[Article in Polish]
Pomorski Z, Rudzki E.
PMID: 4081070 [PubMed - indexed for MEDLINE]
|
65:
Vestn
Otorinolaringol. 1983 Nov-Dec;(6):47-50. |
[Combined effect of propolis and different antibiotics on Staphylococci]
[Article in Russian]
Sytnik IA, Kovalik PV.
PMID: 6659261 [PubMed - indexed for MEDLINE]
|
66:
Minerva
Med. 1983 Sep 15;74(35):2029-32. |
[Bacteriological and clinical notes on otitis externa in saturation.
Double-blind study on the efficacy of prophylactic and therapeutic
preparations]
[Article in Italian]
Marroni A, Arduini R, Conti S.
Microbiological analysis of the variation in the bacterial flora of the
external auditory canal was carried out during 39 immersion in saturated
solutions. A double blind test on the usefulness of prophylactic and
therapeutic preparations was also carried out. Prophylactics. - 5% Al acetate in
H2O (P1), Boric alcohol (P2), lactic acid in H2O (P3, Domeboro (P4), no
prophylactic (P0). After the immersions, a significant increase in Pseudomonas
Aeruginosa and Candida Albicans (p less than 0,01) was noted in the auricular
bacterial flora. Gram positive bacteria in general were considerably reduced (p
less than 0,01). Gram negative bacteria other than pseudomonas. A (p less than
0,3) and coagulase negative straphylococci (p less than 0,03) did not vary
significantly. Prophylactic preparations P1 and P2 were shown to be
significantly more effective than P3, P4 and P0 in preventing the
symptomatology (p less than 0,01). The most effective therapeutic preparation
was found to be a locally applied gentamycinpolymixin association.
Publication Types:
PMID: 6412179 [PubMed - indexed for MEDLINE]
|
67:
Stomatol
Vjesn. 1983;12(3-4):139-42. |
[Scientific findings on propolis and its application in medicine]
[Article in Croatian]
Hajdaragic-Ibricevic H.
PMID: 6592856 [PubMed - indexed for MEDLINE]
|
68:
Pharmazie.
1982 Dec;37(12):864-5. |
Growth inhibition of bacillus subtilis and composition of various
propolis extracts.
Pepeljnjak S, Jalsenjak I, Maysinger D.
The composition of 31 samples of propolis extract was investigated by using
TLC. Ethanol extract of propolis (EEP) prepared from the various propolis
samples differ mainly in quantities of identified compounds, and not in kind of
components present. According to the inhibitory activity against Bacillus
subtilis, the propolis samples were grouped in three categories. It appears
that the galangin content in a sample is a main constituent, which determines
its antibacterial activity.
PMID: 6819589 [PubMed - indexed for MEDLINE]
|
69:
Antibiotiki.
1981 Apr;26(4):268-71. |
[Effect of propolis on Staphylococcus aureus strains resistant to
antibiotics]
[Article in Russian]
Shub TA, Kagramanova KA, Voropaeva SD, Kivman GIa.
The activity of propolis and its combinations with antibiotics against
antibiotic resistant strains of Staphylococcus aureus was studied. It was found
that staphylococcae strains resistant to benzylpenicillin, tetracycline and
erythromycin were mainly sensitive to propolis. It is concluded that there was
synergism in the effect of propolis and antibiotics with respect to antibiotic
resistant strains of Staphylococcus aureus.
PMID: 7235666 [PubMed - indexed for MEDLINE]
|
70:
Cesk
Stomatol. 1980 Jul;80(4):304-7. |
[Antibacterial properties of propolis]
[Article in Slovak]
Madarova L.
PMID: 6931664 [PubMed - indexed for MEDLINE]
|
71:
Stomatologiia
(Mosk). 1980 Jun;59(3):61. |
[Stomapin in the overall treatment of parodontosis and oral mucosal
diseases]
[Article in Russian]
Metrik AZ.
PMID: 6930731 [PubMed - indexed for MEDLINE]
|
72:
Pharmazie.
1979;34(2):103-6. |
[Identification of an antimicrobially active constituent isolated from
propolis (author's transl)]
[Article in German]
Schneidewind EM, Buge A, Kala H, Metzner J, Zschunke A.
On isolating and identifying antimicrobially active propolis constituents, the
authors detected a substance that must be regarded as a mixture of caffeic acid
esters. The caffeic acid moiety was unequivocally identified by various
chemical and spectroscopic methods. The results obtained from the gas
chromatographic study of the alcohol fraction after hydrolysis of the isolated
compound identify benzyl alcohol, phenyl ethyl alcohol and cinnamic alcohol as
ester components. Furthermore, the mass spectroscopic findings are indicative
of the presence of a caffeic acid pentenyl ester in the mixture. Attempts to
separate this ester mixture by recrystallization and thin-layer chromatography
failed.
PMID: 441103 [PubMed - indexed for MEDLINE]
|
73:
Stomatologiia
(Sofiia). 1979 Jan-Feb;61(1):18-22. |
[Clinical results of the treatment of parodontosis with propolis and
lincomycin]
[Article in Bulgarian]
Goranov K, Zarankova V, Velcheva M.
PMID: 299294 [PubMed - indexed for MEDLINE]
|
74:
Pharmazie.
1979;34(2):97-102. |
[On the antimicrobial activity of propolis and propolis constituents
(author's transl)]
[Article in German]
Metzner J, Bekemeier H, Paintz M, Schneidewind E.
After a survey of the literature on the antimicrobial activity of the bee
product propolis, the authors discuss their own findings as compared to the
chemotherapeutical agents streptomycin, oxytetracycline, chloramphenicol,
nystatin, griseofulvin and sulphamerazine. According to the results obtained by
testing 25 isolated constituents on Bacillus subtilis, Staphylococcus aureus,
Candida albicans and Trichophyton mentagrophytes, the antimicrobial properties
of this mixture of natural substances are mainly attributable to the flavonoids
pinocembrin, galangin, pinobanksin, pinobanksin-3-acetate as well as to the
p-coumaric acid benzyl ester and a caffeic acid ester mixture. None of the
isolated substances was as potent as the antibiotics tested for the purpose of
comparison. The relatively good antimycetic activity of the
5,7-dihydroxyflavanone pinocembrin seems noteworthy. Finally, possible
mechanisms of the antimicrobial action of the flavonoids are discussed.
PMID: 108687 [PubMed - indexed for MEDLINE]
|
75:
Mykosen.
1978 Aug;21(8):257-62. |
[Effect of pinocembrin on the course of experimental candida infections
in mice]
[Article in German]
Metzner J, Schneidewind EM.
Pinocembrin (5,7-dihydroxy-flavanon)--a component of the bee product
propolis--was tested for its in vivo activity against Candida albicans in mice.
It was shown that the intravenous infection of AB-Jena mice with 2.5 X 10(5)
Candida albicans cells was a very suitable model. Despite of treatment with
pinocembrin at daily doses of 100 mg/kg body weight the animals as well as the
controls died between the 6th and 24th day after beginning. On the other hand
the animals treated with 5 mg/kg amphotericin B survived the test-period of 30
days. The question of effectiveness of pinocembrin in vivo should be cleared up
in further pharmacokinetic investigations.
PMID: 692545 [PubMed - indexed for MEDLINE]
|
76:
Nord
Vet Med. 1977 Oct;29(10):446-51. |
A new selective medium for the isolation of Listeria monocytogenes.
Gronstol H, Aspoy E.
A new selective medium for the isolation of Listeria monocytogenes (Lm), is
described. The medium contained propolis, nalidixic acid, polymyxin B and
rivanol as selective substances. The new medium (propolis-agar) was compared
with two other selective media and one nonselective medium. No inhibitory
effect was found on the 6 strains of Lm tested, and Lm was easily isolated from
a mixture of Lm and contaminating bacteria. The selective effect was better
than for the two other selective media tested.
PMID: 411112 [PubMed - indexed for MEDLINE]
|
77:
Nord
Vet Med. 1977 Oct;29(10):440-5. |
[Selective effect of propolis in the isolation of Listeria monocytogenes
(author's transl)]
[Article in Norwegian]
Aspoy E.
Propolis is a substance produced by honeybees. It is inhibitory to some
bacteria species, mainly Gram-positive bacteria, but less inhibitory to
Listeria monocytogenes (L.m) than to the other Gram-positive bacteria tested.
In order to obtain selective growth of L.m. from contaminated samples, the
effect of propolis in plating media and broths on various strains of bacteria
was examined. Table I shows the effect of increasing concentrations of propolis
in tryptose-agar (TA). L.m. tolerated higher concentrations of propolis than
Streptococcus viridans and Staphylococcus aureus. L.m. grew well in
tryptosebroth (TB) that contained 0.15 mg propolis pr. ml medium, while
Streptococcus viridans and Streptococcus agalactiae were completely inhibited
as seen in Table II. Table III shows that when serum was added to the agar, the
inhibitory effect was reduced. It can also be seen that Gram-negative bacteria
grew quite well on media that contained 0.19 mg propolis pr. ml. To reduce the
growth of Gram-negative bacteria, nalidixic acid was added to the medium. Table
IV illustrates growth of various species of bacteria in tryptosephosphatebroth (TFB)
with or without propolis and nalidixic acid. Most of the strains tested were
inhibited, but Pseudomonas aeruginosa and to some extent faecal streptococci
were able to grow in the medium that contained the selective substances. As a
conclusion it seems that propolis may be a valuable additive to a medium for
the selective isolation of L.m.
PMID: 411111 [PubMed - indexed for MEDLINE]
|
78:
Zh
Ushn Nos Gorl Bolezn. 1977 Jul-Aug;(4):82-3. |
[Bacterial flora and its sensitivity to propolis and antibiotics in
acute and chronic highmoritis]
[Article in Russian]
Kovalik PV.
PMID: 930362 [PubMed - indexed for MEDLINE]
|
79:
Arzneimittelforschung.
1977 Jul;27(7):1395. |
Biological properties and clinical application of propolis. III.
Investigation of the sensitivity of Staphylococci isolated from pathological
cases to ethanol extract of propolis (EEP). Attempts on inducing resistance in
laboratory Staphylococcus strain to EEP.
Scheller S, Tustanowski J, Kurylo B, Paradowski Z, Obuszko Z.
Staphylococci isolated from pathological material exhibited a reduced
sensitivity to ethanol extract of propolis (EEP) in 90% of cases. No
cross-resistance of the staphylococci to EEP and to any commonly used
antibiotics was found. The induction of resistance to EEP in laboratory strain
of Staphylococcus aureus (Oxford 209 P) can be achieved already after serial
passages on nutrient media containing EEP. Culturing Staphylococcus resistant
to EEP in an environment devoid of this compound caused a remission to
sensitivity of the strain investigated.
PMID: 578459 [PubMed - indexed for MEDLINE]
|
80:
Antibiotiki.
1976 May;21(5):422-3. |
[Fractionation of the mixture of volatile with steam components of
propolis and the study of their antimicrobial activity]
[Article in Russian]
Kivalkina VP, Rybkina NI, Barskov AA, Geras'kin IM, Talan VA.
PMID: 828845 [PubMed - indexed for MEDLINE]
|
81:
Pharmazie.
1975 Dec;30(12):799-800. |
[Bioautographic detection of the antimicrobial active constituents of
propolis]
[Article in German]
Metzner J, Bekemeier H, Schneidewind E, Schwaiberger R.
PMID: 815918 [PubMed - indexed for MEDLINE]
|
82:
Dermatol
Monatsschr. 1973 Apr;159(4):443-9. |
[Microbiological, pharmacological and clinical studies on the efficiency
of propolis]
[Article in German]
Bekemeier H, Braun W, Friedrich E, Kala H, Metzner J, Schneidewind E, Schwaiberger R, Wozniak KD.
PMID: 4726636 [PubMed - indexed for MEDLINE]
|
83:
Antibiotiki.
1973 Mar;18(3):261-3. |
[Study of combined effect of antibiotics and propolis]
[Article in Russian]
Kivalkina VP, Gosrshumova VI.
PMID: 4587465 [PubMed - indexed for MEDLINE]
|
84:
Antibiotiki.
1973 Mar;18(3):259-61. |
[Synergistic effects of propolis and some antibacterial agents]
[Article in Russian]
Cherniak NF.
PMID: 4587464 [PubMed - indexed for MEDLINE]