PROPOLEOS ANTINFLAMATORIO
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Items 1 - 18 of 18 |
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1:
Int
Immunopharmacol. 2005 Feb;5(2):359-68. |
Effects of Brazilian and Bulgarian propolis on bactericidal activity of
macrophages against Salmonella Typhimurium.
Orsi RO, Sforcin JM, Funari SR, Bankova V.
Department of Production and Animal Exploration-School of Veterinary Medicine
and Animal Husbandry-UNESP, 18618-000 Botucatu, SP,
Propolis has been used in folk medicine since ancient times due to its many biological
properties, such as antimicrobial, antiinflammatory, antioxidant,
immunomodulatory activities, among others. Macrophages play an important role
in the early phase of Salmonella infection. In this work, macrophages were
prestimulated with Brazilian or Bulgarian propolis and subsequently challenged
with Salmonella Typhimurium at different macrophage/bacteria ratio. After 60
min of incubation, cells were harvested with Triton-X to lyse the macrophages. To
assess the bactericidal activity, the number of colony-forming units (CFU) of
S. typhimurium was determined by plating 0.1 mL in Mueller Hinton agar. After
24 h, CFU were counted, and the percentage of bactericidal activity was
obtained. Propolis from
PMID: 15652765 [PubMed - indexed for MEDLINE]
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2:
Biol
Pharm Bull. 2003 Apr;26(4):487-91. |
Caffeic acid phenethyl ester (CAPE) analogues: potent nitric oxide
inhibitors from the
Nagaoka T, Banskota AH, Tezuka Y, Midorikawa K, Matsushige K, Kadota S.
The MeOH and water extracts of the
PMID: 12673030 [PubMed - indexed for MEDLINE]
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3:
Fitoterapia.
2002 Nov;73 Suppl 1:S21-9. |
Antioxidant activity of propolis: role of caffeic acid phenethyl ester
and galangin.
Russo A, Longo R, Vanella A.
Department of Biochemistry, Medical Chemistry and Molecular Biology, University
of Catania, V.le A. Doria 6, 95125, Catania, Italy. alrusso@mbow.unict.it
Propolis, a natural product produced by the honeybee, has been used for
thousands of years in folk medicine for several purposes. The extract contains
amino acids, phenolic acids, phenolic acid esters, flavonoids, cinnamic acid,
terpenes and caffeic acid. It possesses several biological activities such as
antiinflammatory, immunostimulatory, antiviral and antibacterial. The exact
mode of physiological or biochemical mechanisms responsible for the medical
effects, however, is yet to be determined. In this work, we have investigated
the antioxidant activity of a propolis extract deprived of caffeic acid
phenethyl ester (
PMID: 12495706 [PubMed - indexed for MEDLINE]
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4:
Curr
Eye Res. 2001 Oct;23(4):291-7. |
Effect of caffeic acid phenethyl ester on corneal neovascularization in
rats.
Totan Y, Aydin E, Cekic O, Cihan Dagloglu M,
Borazan M, Daglioglu K, Gultek A.
Department
of Ophthalmology,
PURPOSE: Caffeic acid phenethyl ester (
PMID: 11852431 [PubMed - indexed for MEDLINE]
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5:
Phytother
Res. 2001 Nov;15(7):561-71. |
Recent progress in pharmacological research of propolis.
Banskota AH, Tezuka Y, Kadota S.
Department of Natural Products Chemistry,
Propolis is a resinous hive product collected by honeybees from various plant
sources. It is a popular folk medicine possessing a broad spectrum of biological
activities. It has also been used as a health drink in various Asian, European
and American countries. Several groups of researchers have focused their
attention on the biological activity of propolis and its active principles. Many
scientific articles are published every year in different international
journals related to the pharmacological properties of propolis. This review
article compiles recent findings (since 1995) on the pharmacological properties
of propolis focusing on its antihepatotoxic, antitumour, antioxidative,
antimicrobial and antiinflammatory properties. The possible mechanism of action
of propolis as well as the active compounds are discussed. Copyright 2001 John Wiley & Sons, Ltd.
Publication Types:
·
Review
PMID: 11746834 [PubMed - indexed for MEDLINE]
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6:
Arzneimittelforschung.
2000 Apr;50(4):373-9. |
Antiapoptotic effects of propolis extract and propol on human
macrophages exposed to minimally modified low density lipoprotein.
Claus R, Kinscherf R, Gehrke C, Bonaterra G, Basnet P, Metz J, Deigner HP.
An aqueous extract of propolis and the phenolic component of propolis, propol,
were assayed for antioxidative and antiapoptotic properties. Both additions
inhibited Cu(2+)-initiated low density lipoprotein (LDL) oxidation as
characterized by a reduction of the lag time, reduced the increase of relative
electrophoretic mobility during oxidation and markedly diminished apoptosis of
human macrophages exposed to minimally modified (mmLDL). Moreover, aqueous propolis
extract and propol blocked the mmLDL-induced decrease of glutathione (GSH) and
the activation of the transcription factor NF-kappa B in these cells. The
potent phenolic antioxidant propol thus expands the capability of cells to
neutralize oxidative stress and to prevent apoptosis and is therefore suggested
to significantly contribute to the antiinflammatory and antioxidative effects
of propolis.
PMID: 10800636 [PubMed - indexed for MEDLINE]
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7: Proc Natl Acad Sci U S A. 1996 Aug
20;93(17):9090-5. |
Caffeic acid phenethyl ester is a potent and specific inhibitor of
activation of nuclear transcription factor NF-kappa B.
Natarajan K, Singh S, Burke TR Jr, Grunberger D, Aggarwal BB.
Department of Molecular Oncology, University of
Caffeic acid phenethyl ester (
PMID: 8799159 [PubMed - indexed for MEDLINE]
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8:
Orv Hetil.
1996 Jun 23;137(25):1365-70. |
Comment in:
·
Orv
Hetil. 1996 Jun 23;137(25):1363-4.
[Local treatment of rheumatic diseases with propolis compounds]
[Article in Hungarian]
Siro B, Szelekovszky S, Lakatos B, Mady G, Szathmari E, Karanyi Z.
Debreceni Orvostudomanyi Egyetem I. Belgyogyaszati Klinika.
The authors conducted a single blind, placebo controlled local therapy trial on
a total of 190 patients involving the use of materials (i) topically and (ii)
by iontophoresis for pain and/or inflammation of the organs of movement. The
materials used comprised of the following: (i) purified propolis and propolis
saturated with antiinflammatory trace metal elements and (ii) propolis
saturated with trace metal elements and poplar bud ointment saturated with
trace metal elements also. Both methods of application using all the three
preparations significantly improved symptoms. The preparations saturated with
metallic ions were more effective. The mild effect of the placebo treatment is
explained by the treatment procedure itself. Side
effects were not observed.
Publication Types:
PMID: 8757085 [PubMed - indexed for MEDLINE]
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9:
Drugs
Exp Clin Res. 1995;21(6):229-36. |
The use of aqueous propolis extract against radiation-induced damage.
El-Ghazaly MA, Khayyal MT.
Department of Drug Radiation Research, National Centre for Radiation Research
and Technology,
Whole body exposure to gamma radiation has been experimentally shown to
exaggerate inflammatory responses and to enhance the release of mediators. A
thirteen per cent aqueous extract of propolis (bee glue) was previously shown
to have potent antiinflammatory activity. The present study was carried out to
show whether the extract could influence the exaggerated inflammatory response
in irradiated animals. Rats were exposed to acute (2 and 6 Gy) &
fractionated (1 Gy/week) doses of gamma ionizing radiation. Treatment with the
aqueous extract orally (5 ml/kg) before and after radiation exposure markedly
reduced the exaggerated paw oedema response to carrageenan. In the acute phase
of adjuvant-induced arthritis, exposure to ionizing radiation caused an
increase in serum acid phosphatase level. Malondialdehyde concentration in
plasma and superoxide dismutase activity in blood significantly increased. Treatment
with aqueous propolis extract prior to irradiation reduced malondialdehyde
concentration in plasma and normalized the serum acid phosphatase level. The
extract stimulated the release of superoxide dismutase enzyme. Aqueous propolis
extract could possibly be of therapeutic value in protecting against
inflammatory responses induced by gamma radiation.
PMID: 8907698 [PubMed - indexed for MEDLINE]
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10: Z Naturforsch [C]. 1994 Jan-Feb;49(1-2):39-43. |
Biochemical activities of propolis-extracts. III. Inhibition of
dihydrofolate reductase.
Strehl E, Volpert R, Elstner EF.
Institut fur Botanik und Mikrobiologie, Biochemisches Labor, Technische Universitat
Munchen.
Ethanolic and aqueous extracts of the natural compound PROPOLIS indicate
substantial antiinflammatory functions as well as antibiotic activities in
vitro and in vivo. The exact mode of physiological or biochemical mechanisms
responsible for the medical effects, however, is all but clear. The
standardization on the basis of quantitative determination of prominent
components of these extracts have been substituted recently by simple
biochemical model reactions including photodynamic properties. In this
communication we report on the inhibitory activity of an aqueous extract of
propolis on the enzyme dihydrofolate reductase. This activity may at least
partially be due to the content of caffeic acid, as revealed by HPLC
chromatography and comparative activity tests of representative ingredients of
the propolis extract. This result may explain some of the protective functions
of propolis, similar to those shown for several "non-steroidal
antiinflammatory drugs", NSAIDs.
PMID: 8148008 [PubMed - indexed for MEDLINE]
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11: Z Naturforsch [C]. 1993
Nov-Dec;48(11-12):858-62. |
Biochemical activities of propolis extracts. II. Photodynamic
activities.
Volpert R, Elstner EF.
Institut fur Botanik und Mikrobiologie, Biochemisches Labor, Technische
Universitat Munchen, Bundesrepublik Deutschland.
Ethanolic and aqueous extracts of the "bee glue" Propolis exhibit
antioxidative properties and are used as antiinflammatory drugs in folk
medicine. In order to standardize the principle activities of prominent
components of these extracts, simple biochemical tests have been introduced in
the preceding paper. These activity tests prove the high antioxidative and
inhibitory capacities of aqueous and ethanolic extracts of propolis in vitro. In
the present communication we report on experiments documenting photodynamic quenching
properties of these extracts. Using riboflavin, rose bengal or hematoporphyrin
as photoactivators and ketomethylthiobutyric acid or crocin as indicators, the
protective functions of propolis preparations can be demonstrated. The results
indicate that the aqueous extracts are more active than the corresponding
ethanolic preparation.
PMID: 8297423 [PubMed - indexed for MEDLINE]
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12: Z Naturforsch [C]. 1993
Nov-Dec;48(11-12):851-7. |
Biochemical activities of propolis extracts. I. Standardization and
antioxidative properties of ethanolic and aqueous derivatives.
Volpert R, Elstner EF.
Institut fur Botanik und Mikrobiologie, Biochemisches Labor, Technische
Universitat Munchen, Bundesrepublik Deutschland.
Ethanolic extracts of Propolis are used as antiinflammatory and wound healing
drugs since ancient times. In order to facilitate a comparison of different
extracts, the standardization on the basis of quantitative determination of
prominent components of these extracts has been substituted for simple
biochemical "activity" tests. One of these activity tests bases on
the inhibition of peroxidase-catalyzed oxidation of indole acetic acid
indicating the presence of a defined mixture of monophenolic and diphenolic
compounds. Other tests (diaphorase-catalyzed reductions and xanthine
oxidase-catalyzed oxidations) demonstrate significant radical scavenging
properties. Water-soluble extracts of propolis exhibit higher antioxidative and
inhibitory activities as compared to the ethanolic extract.
PMID: 8297422 [PubMed - indexed for MEDLINE]
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13:
Cancer
Res. 1993 Mar 15;53(6):1255-61. |
Inhibition of tumor promoter-mediated processes in mouse skin and bovine
lens by caffeic acid phenethyl ester.
Frenkel K, Wei H, Bhimani R, Ye J, Zadunaisky JA,
Huang MT, Ferraro T, Conney AH, Grunberger D.
Department
of Environmental Medicine, New York University Medical Center, New York
10016-6451.
Caffeic acid phenethyl ester (CAPE) was isolated from propolis (a product of
honeybee hives) that has been used in folk medicine as a potent
antiinflammatory agent. CAPE is cytotoxic to tumor and virally transformed but
not to normal cells. Our main goal was to establish whether CAPE inhibits the
tumor promoter (12-O-tetradecanoylphorbol-13-acetate)-induced processes
associated with carcinogenesis. Topical treatment of SENCAR mice with very low
doses (0.1-6.5 nmol/topical treatment) of CAPE strongly inhibits the following
12-O-tetradecanoylphorbol-13-acetate-mediated oxidative processes that are
considered essential for tumor promotion: (a) polymorphonuclear leukocyte
infiltration into mouse skin and ears, as quantified by myeloperoxidase
activity; (b) hydrogen peroxide (H2O2) production; and (c) formation of
oxidized bases in epidermal DNA, as measured by 5-hydroxymethyluracil and
8-hydroxylguanine. A 0.5-nmol dose of CAPE suppresses the oxidative burst of
human polymorphonuclear leukocytes by 50%. At higher doses (1-10 mumol), CAPE
inhibits edema and ornithine decarboxylase induction in CD-1 and SENCAR mice. Interestingly,
we discovered that 12-O-tetradecanoylphorbol-13-acetate-induced H2O2 production
in bovine lenses also is inhibited by CAPE. Cumulatively, these findings point
to CAPE as being a potent chemopreventive agent, which may be useful in
combating diseases with strong inflammatory and/or oxidative stress components,
i.e., various types of cancer and possibly cataract development.
PMID: 7680281 [PubMed - indexed for MEDLINE]
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14:
Drugs
Exp Clin Res. 1993;19(5):197-203. |
Mechanisms involved in the antiinflammatory effect of propolis extract.
Khayyal MT, el-Ghazaly MA, el-Khatib AS.
Department of Pharmacology, Faculty of Pharmacy, Cairo University, Egypt.
Propolis is a natural product produced by the honey bee. The extract contains
amino acids, flavanoids, terpenes and cinnamic acid derivatives. In various in
vitro models propolis extract was shown to inhibit platelet aggregation and to
inhibit eicosanoid synthesis, suggesting that it might have potent
antiinflammatory properties. A 13% aqueous extract was tested orally in three
dose levels (1, 5 and 10 ml/kg) on the carrageenan rat paw oedema model and on
adjuvant-induced arthritis in rats. In both models, the extract showed potent
dose-related antiinflammatory activity, which compared well with that of
diclofenac (as a reference standard). The extract was then tested on an
isolated sensitized guinea pig lung preparation to study its effect on the
release of prostaglandins, leukotrienes and histamine. It is concluded that
propolis extract has potent antiinflammatory properties in vivo. Its activity
can be well correlated with its effects on the release of various mediators of
inflammation.
PMID: 7513636 [PubMed - indexed for MEDLINE]
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15:
J
Ethnopharmacol. 1991 Oct;35(1):77-82. |
Antibacterial, antifungal, antiamoebic, antiinflammatory and antipyretic
studies on propolis bee products.
Dobrowolski JW,
Vohora SB, Sharma K, Shah SA, Naqvi SA, Dandiya PC.
Institute
of Management and Protection of Environment, Krakow, Poland.
PMID: 1753797 [PubMed - indexed for MEDLINE]
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16: Rev Chir Oncol Radiol O R L Oftalmol
Stomatol Ser Stomatol. 1989 Apr-Jun;36(2):91-8. |
[Apiphytotherapeutic original preparations in the treatment of chronic
marginal parodontopathies. A clinical and microbiological study]
[Article in Romanian]
Gafar M, Dumitriu H, Dumitriu S, Guti L.
The paper presents results obtained by the treatment of chronic marginal
parodontopathies with natural products of apiarian derivatives and vegetal
extracts. These are original preparations such as Proparodont, sage extracts,
watercress extracts, etc., by comparison with other similar existing products,
and with zinc chloride. The clinical study evaluated the "inflammation
status of the marginal prodontium" on the basis of variations in the PMA
index. The microbiological study has established the bacteriostatic and the
bactericidal activities of the products employed. The results obtained stress
the high antimicrobial activity of the original products called Proparodont,
and stress its antimycotic effects, especially against Candida albicans. The
blackwort (Symphytum off.) extracts have a good repair effect, especially after
surgical procedures. The complex original products based on propolis and
vegetal extracts are indicated in the treatment of inflammatory lesions of the
gingivo-parodontal tissues, and of the buccal mucosa. They also have
antimicrobial effects, as well as antimycotic, antiinflammatory and antiscar
effects. They de not have side effects which are characteristic for other
medicinal drugs employed in the treatment of chronic marginal parodontopathies.
PMID: 2535077 [PubMed - indexed for MEDLINE]
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17: Vestn Khir Im I I Grek. 1985
May;134(5):119-22. |
[Use of propolis in the treatment of local suppurative infection]
[Article in Russian]
Tsarev NI, Petrik EV, Aleksandrova VI.
Experience with the treatment of 460 patients with panaritium, abscesses,
phlegmons, infectious wounds have shown that propolis is an expedient remedy
(in additional to the the routine treatment). They have shown the stimulating,
antiinflammatory and anti-microbial action of propolis.
PMID: 4035908 [PubMed - indexed for MEDLINE]
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18:
Agents
Actions Suppl. 1982;10:129-34. |
Influence of flavonoids on capillary permeability, carrageenin edema and
histamine and PGE2 spasms.
Metzner J, Bekemeier H, Weber FG.
Bioflavonoids from propolis and 6-halogenated flavanones were tested with
respect to their effects on increased capillary permeability and to their
antiinflammatory and antispasmodic actions, respectively. The 5,7,8-trimethoxy-
and 6-fluorflavanone seem to be the best compounds tested.
PMID: 6956213 [PubMed - indexed for MEDLINE]