PROPOLEOS HEPATITIS
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Items 1 - 8 of 8 |
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1:
Toxicology.
2004 Mar 1;196(1-2):87-93. |
Antioxidative natural product protect against econazole-induced liver
injuries.
Liu CF, Lin CH, Lin CC, Lin YH, Chen CF, Lin CK, Lin SC.
The study objective of this research is in order to investigate the
hepatoprotective and therapeutic effects of propolis ethanol extract (PEE) on
acute econazole-induced liver injury. Positive control of various
concentrations of PEE on liver function and the dose-response relationship of
liver injury induced by various doses of econazole were firstly observed from
biochemical assay of serum level of aspartate transaminase (SGOT) and serum
alanine transaminase (SGPT) and histopathological microscopic examination. The
hepatoprotective effects of various concentration of PEE on liver damage
induced by hepatotoxic dose (300 mg/kg) of econazole were observed by the
obvious decrement of SGOT and SGPT level and further confirmed by
hepatohistological microscopic examination. The inhibitory effects of PEE on
FeCl(2)-induced (in vitro) or econazole-induced (in vivo) lipid peroxidation
were investigated from the measurement of the formed malonic dialdehyde (MDA)
level in the rat liver homogenate. The IC(50) (microM) of various
concentrations of PEE in the superoxide scavenging activity in econazole (300
mg/kg)-damaged rat liver homogenate were assessed by cytochrome c reduction
method and compared with that of (+)-alpha-tocopherol. It could be postulated
that the hepatoprotective effect of PEE may be, at least in part, due to their
inhibitory ability on membrane lipid peroxidation and free radical formation or
due to their free radical scavenging ability.
PMID: 15036759 [PubMed - indexed for MEDLINE]
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2:
Phytother
Res. 2003 Mar;17(3):250-3. |
The protective effects of Propolis on
hepatic injury and its mechanism.
Seo KW, Park M, Song YJ, Kim SJ, Yoon KR.
Toxicology Department, National Institute of Toxicological
AbstractPropolis (PP) is a sticky substance that is collected from plants by
honeybees. The purpose of this study was to investigate the protective effects
of PP on hepatotoxicity induced by acetaminophen (AA, paracetamol) and the
mechanism of its hepatoprotective effect. In rat hepatocyte culture,
pretreatment with PP (1, 10, 100, 200 and 400 microg/mL, 24 h) significantly
decreased the cytotoxicity of AA (
PMID: 12672155 [PubMed - indexed for MEDLINE]
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3:
J
Ethnopharmacol. 2000 Sep;72(1-2):239-46. |
Cytotoxic, hepatoprotective and free
radical scavenging effects of propolis from
Banskota AH, Tezuka Y, Adnyana IK, Midorikawa K, Matsushige K, Message D, Huertas AA, Kadota S.
Department
of Natural Products Chemistry,
Propolis is a resinous hive product collected by honeybees from various plant
sources. The composition of the propolis depends upon the time, vegetation and
the area of collection. Thus, quality evaluation of the propolis is important,
before use in food and beverages. For this propose three different biological
activities were carried out, i.e. 1,1-diphenyl-2-picrylhydrazyl (DPPH) free
radical scavenging activity, cytotoxicity and hepatoprotective activity, of
MeOH and water extracts of nine different propolis from Brazil, Peru, the
Netherlands and China. The results showed that water extracts of six Brazilian
and a Chinese propolis possessed stronger DPPH free radical scavenging activity
than the corresponding MeOH extract, whereas in the case of Netherlands and
Peruvian propolis MeOH extract exhibited stronger DPPH free radical scavenging
activity. The MeOH extracts of all propolis possessed stronger cytotoxicity
than the corresponding water extract towards murine colon 26-L5 carcinoma and
human HT-1080 fibrosarcoma cells. The result of hepatoprotective activity of
Brazilian propolis on D-galactosamine (D-GalN)/tumor necrosis factor-alpha
(TNF-alpha)-induced cell death in primary cultured mouse hepatocytes were found
in accordance with the grade set up by beekeepers in Brazil.
PMID: 10967477 [PubMed - indexed for MEDLINE]
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4:
Biol
Pharm Bull. 1999 Nov;22(11):1237-9. |
Effect of propolis extract on
D-galactosamine-induced hepatic injury in rats.
Sugimoto Y, Tarumi T, Kaneko Y, Isayama S, Kawai N, Sugimoto H, Yamada H, Kamei C.
Department
of Pharmacology, Faculty of Pharmaceutical Sciences,
The preventive effect of propolis extract on D-galactosamine-induced hepatic
injury was examined in rats. Serum aspartate aminotransferase (AST) and alanine
aminotransferase (ALT) activities were significantly increased at 24 h after
intraperitoneal injection of D-galactosamine (400 mg/kg) in the animals. Propolis
extract was administered orally three times in doses of 3 or 30 mg/kg at 18 h
and 1 h before and 8 h after D-galactosamine injection. The extract itself and
the vehicle alone (dextran) caused no significant changes in serum AST or ALT
activities. Treatment with the extract dose-dependently prevented the increases
in serum AST and ALT activities induced by D-galactosamine, and significant
inhibition was observed at a dose of 30 mg/kg. These results suggested that
propolis extract may have an ameliorating effect on hepatic dysfunction.
PMID: 10598035 [PubMed - indexed for MEDLINE]
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5:
Pharmacol
Res. 1997 Jan;35(1):1-4. |
Effects of Cuban red propolis on
galactosamine-induced hepatitis in rats.
Rodriguez S, Ancheta O, Ramos ME, Remirez D, Rojas E, Gonzalez R.
Electron
Microscopy Laboratory,
Using transmission electron microscopy and biochemical analysis, the effect of
cuban red propolis against hepatitis induced by 1,000 mg kg-1 of galactosamine
in rats was studied. An ethanolic extract of propolis was prepared and it was
given to rats at doses of 10, 50 and 100 mg kg-1, 30 min before the
hepatotoxin. Propolis extract prevented hepatocytes alterations induced by
galactosamine. It was mainly seen in rough endoplasmic reticulum, Golgi
complex, nucleus and plasma membrane of hepatocytes. Propolis extract induced
reversion of the increased activity of alanine aminotransferase and
malondialdehyde concentration in the serum of rats treated with galactosamine.
The probable role of antioxidant activity of propolis in the prevention of
hepatitis is discussed in this paper.
PMID: 9149308 [PubMed - indexed for MEDLINE]
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6:
Arch
Med Res. 1996 Autumn;27(3):285-9. |
Histopathological evaluation on the effect
of red propolis on liver damage induced by CCl4 in rats.
Merino N, Gonzalez R, Gonzalez A, Remirez D.
Departamento de Farmacologia y Toxicologia, Centro Nacional de Investigaciones
Cientificas, Havana, Cuba.
A
histopathological evaluation was performed on liver of rats treated with carbon
tetrachloride (CCl4) and 25,50 and 100 mg/kg of Cuban red propolis (RP)
extract. Additionally, alanine aminotransferase (ALT) in serum and liver
triglycerides were determined in all animals. The morphometric study included
the count of ballooned cells at the zone III of the Rappaport acini and the
assessment of a software program to estimate the extension of steatosis area. A
significant reduction of ballooned cells count in liver was observed at three
dose levels of RP extract with respect to rats treated only with CCl4. Also, a
certain reduction of steatosis degree as well as decreased concentration of
liver triglycerides and ALT activity were found in three groups of rats treated
with RP extract and CCl4 in relation to those treated with the hepatotoxin.
Taken together, the histopathological and biochemical findings show
hepatoprotective effects of RP extract in CCl4-induced liver damage in rats,
probably due to the antioxidant effect of RP.
PMID: 8854383 [PubMed - indexed for MEDLINE]
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7: Eksp Klin Farmakol. 1994
Jul-Aug;57(4):39-42. |
[The liver-protective properties of the pediatric drug form of propolis
in animals of different age groups]
[Article in Russian]
Drogovoz SM, Tikhonov AI, Slyshkov VV, Sal'nikova SI.
The pharmacological activity of a pediatric formulation of the phenolic
hydrophobic drug propolis was studied in the experiments on albino rats of
various age with toxic liver damages of various duration and in acute hepatic
ischemia. In all models of hepatic abnormalities, the drug was found to show
antioxidative properties which were moderate (30-60%). In addition, there were
improvements in hepatic secretion of bile, cholic acids, and cholesterol. On
the other hand, the membrane-stabilizing effect of the drug was exerted in not
all the tested models of hepatic damage.
PMID: 7950783 [PubMed - indexed for MEDLINE]
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8:
Virologie.
1980 Oct-Dec;31(4):273-8. |
Investigations concerning the action of serveral
chemical and biological agents on HBsAg.
Morfei A, Burducea O, Neuman R, Cajal N, Copelovici Y, Crisan I.
Native and purified
HBsAg preparations were subjected in vitro to the action of cetylpyridinium
bromide (Bromocet), hibitan-chlorhexidine (Hibiscrub), chloramine B and
propolis extract, at different concentrations and for various time intervals.
The effect of these agents on the serological reactivity of HBsAg was tested by
electroimmunodiffusion (EID) and radioimmunoassay (RIA). Chloramine B and the
propolis extract had a significant inhibitory effect-ascertained by both EID
and RIA - on purified HBsAg, but not on the native preparation. The inhibition
exerted by Bromocet and Hibiscrub indicated by EID results was not confirmed by
RIA.
PMID: 7257176 [PubMed - indexed for MEDLINE]